Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase | 0.0324 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0324 | 1 | 0.5 |
Onchocerca volvulus | 0.0324 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0324 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0324 | 1 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0324 | 1 | 0.5 |
Schistosoma mansoni | pol-related | 0.0324 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0324 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0324 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0324 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0324 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0324 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0324 | 1 | 1 |
Onchocerca volvulus | 0.0324 | 1 | 0.5 | |
Giardia lamblia | Aldose reductase | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0324 | 1 | 0.5 |
Onchocerca volvulus | 0.0324 | 1 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0324 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0324 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0324 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0324 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0324 | 1 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0324 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0324 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0324 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0324 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0324 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0324 | 1 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0324 | 1 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0324 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0324 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0324 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0324 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0324 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0324 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0324 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0324 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0324 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0324 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0324 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0324 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0324 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0324 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0324 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0324 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0324 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0324 | 1 | 1 |
Onchocerca volvulus | 0.0324 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase | 0.0324 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0324 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0324 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0324 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0324 | 1 | 0.5 |
Onchocerca volvulus | 0.0324 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0324 | 1 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0324 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0324 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0324 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0324 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0324 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0324 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0324 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0324 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0324 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0324 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0324 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0324 | 1 | 0.5 |
Onchocerca volvulus | 0.0324 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Increase in ear thickness (functional) | = 4.1 1/100mm | Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 50 mg/kg | ChEMBL. | 3512827 |
Increase in ear thickness (functional) | = 4.1 1/100mm | Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 50 mg/kg | ChEMBL. | 3512827 |
Increase in ear thickness (functional) | = 4.2 1/100mm | Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 400 mg/kg | ChEMBL. | 3512827 |
Increase in ear thickness (functional) | = 4.2 1/100mm | Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 400 mg/kg | ChEMBL. | 3512827 |
Inhibition (functional) | = 20.8 % | Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 400 mg/kg | ChEMBL. | 3512827 |
Inhibition (functional) | = 20.8 % | Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 400 mg/kg | ChEMBL. | 3512827 |
Inhibition (functional) | = 22.6 % | Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 50 mg/kg | ChEMBL. | 3512827 |
Inhibition (functional) | = 22.6 % | Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 50 mg/kg | ChEMBL. | 3512827 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.