Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0954 | 0.2692 | 1 |
Mycobacterium ulcerans | DNA polymerase I | 0.0054 | 0.0102 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0954 | 0.2692 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0054 | 0.0102 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0054 | 0.0102 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0954 | 0.2692 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0954 | 0.2692 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0954 | 0.2692 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.2538 | 0.7254 | 0.5 |
Treponema pallidum | DNA polymerase I (polA) | 0.0054 | 0.0102 | 0.5 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0054 | 0.0102 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0954 | 0.2692 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.0054 | 0.0102 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0954 | 0.2692 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0954 | 0.2692 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 2 ug ml-1 | In vitro antimicrobial activity against penicillin-intermediate S. pneumoniae 49619 | ChEMBL. | 12930152 |
MIC (functional) | = 8 ug ml-1 | In vitro antimicrobial activity against methicillin resistant S. aureus 27660 | ChEMBL. | 12930152 |
MIC (functional) | = 8 ug ml-1 | In vitro antimicrobial activity against vancomycin-susceptible E. faecalis 29212 | ChEMBL. | 12930152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.