Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | v-rel avian reticuloendotheliosis viral oncogene homolog A | References | |
Homo sapiens | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Starlite/ChEMBL | References |
Homo sapiens | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | References | |
Homo sapiens | jun proto-oncogene | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Echinococcus granulosus | jun protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Brugia malayi | bZIP transcription factor family protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Echinococcus multilocularis | jun protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0155 | 0.2552 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0155 | 0.2552 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2552 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0155 | 0.2552 | 0.1956 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0155 | 0.2552 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0155 | 0.2552 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0155 | 0.2552 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0155 | 0.2552 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0155 | 0.2552 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0155 | 0.2552 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0155 | 0.2552 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0155 | 0.2552 | 0.1956 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0374 | 1 | 1 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0155 | 0.2552 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0155 | 0.2552 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0155 | 0.2552 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0155 | 0.2552 | 0.1956 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0155 | 0.2552 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0155 | 0.2552 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0155 | 0.2552 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0155 | 0.2552 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0155 | 0.2552 | 0.5 |
Brugia malayi | bZIP transcription factor family protein | 0.0101 | 0.0741 | 0.2904 |
Plasmodium vivax | RNA helicase-1, putative | 0.0155 | 0.2552 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0155 | 0.2552 | 0.1956 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0155 | 0.2552 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10 uM | Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells | ChEMBL. | 11052805 |
IC50 (binding) | > 10 uM | Concentration required to inhibit nuclear factor-kappa B) mediated transcriptional activation in human Jurkat T-cells. | ChEMBL. | 11052805 |
IC50 (binding) | > 10 uM | Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells | ChEMBL. | 11052805 |
IC50 (binding) | > 10 uM | Concentration required to inhibit nuclear factor-kappa B) mediated transcriptional activation in human Jurkat T-cells. | ChEMBL. | 11052805 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.