Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.1007 | 0.0868 | 0.0809 |
Onchocerca volvulus | 0.9259 | 1 | 0.5 | |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.1007 | 0.0868 | 0.0809 |
Loa Loa (eye worm) | hypothetical protein | 0.9259 | 1 | 1 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.1007 | 0.0868 | 0.0809 |
Loa Loa (eye worm) | hypothetical protein | 0.1007 | 0.0868 | 0.0708 |
Echinococcus granulosus | translocator protein | 0.9259 | 1 | 1 |
Schistosoma mansoni | voltage-gated cation channel | 0.1007 | 0.0868 | 0.0868 |
Loa Loa (eye worm) | hypothetical protein | 0.9259 | 1 | 1 |
Schistosoma mansoni | peripheral-type benzodiazepine receptor | 0.9259 | 1 | 1 |
Mycobacterium ulcerans | tryptophan-rich sensory protein | 0.9259 | 1 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.068 | 0.0506 | 0.0445 |
Onchocerca volvulus | 0.9259 | 1 | 0.5 | |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.1007 | 0.0868 | 0.0809 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.1007 | 0.0868 | 0.0809 |
Loa Loa (eye worm) | hypothetical protein | 0.9259 | 1 | 1 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.1007 | 0.0868 | 0.0809 |
Loa Loa (eye worm) | calcium channel | 0.1007 | 0.0868 | 0.0708 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.1007 | 0.0868 | 0.0708 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.1007 | 0.0868 | 0.0809 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.1007 | 0.0868 | 0.0809 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.1007 | 0.0868 | 0.0809 |
Schistosoma mansoni | microtubule-associated protein tau | 0.068 | 0.0506 | 0.0506 |
Loa Loa (eye worm) | hypothetical protein | 0.9259 | 1 | 1 |
Onchocerca volvulus | 0.9259 | 1 | 0.5 | |
Echinococcus multilocularis | translocator protein | 0.9259 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.068 | 0.0506 | 0.0445 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.1007 | 0.0868 | 0.0868 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.1007 | 0.0868 | 0.0868 |
Brugia malayi | hypothetical protein | 0.3738 | 0.3891 | 0.3784 |
Onchocerca volvulus | 0.9259 | 1 | 0.5 | |
Echinococcus granulosus | voltage dependent calcium channel | 0.1007 | 0.0868 | 0.0809 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.52 nM | Inihibition of human VCAM binding to VLA-4 of Ramos cells in ELISA | ChEMBL. | 11140722 |
IC50 (binding) | = 0.52 nM | Inihibition of human VCAM binding to VLA-4 of Ramos cells in ELISA | ChEMBL. | 11140722 |
IC50 (binding) | = 20 nM | Inhibition of human VCAM and Ramos cell VLA-4 interaction | ChEMBL. | 11140722 |
IC50 (binding) | = 20 nM | Inhibition of human VCAM and Ramos cell VLA-4 interaction | ChEMBL. | 11140722 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.