Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0049 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0049 | 0 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Brugia malayi | AKH receptor | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0049 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0049 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0049 | 0 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0049 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0049 | 0 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0049 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0049 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Brugia malayi | Serotonin receptor | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | RE15519p | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0049 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Brugia malayi | follicle stimulating hormone receptor | 0.0049 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0153 | 1 | 1 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0049 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0066 | 0.1654 | 0.1654 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0133 | 0.8046 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0097 | 0.4606 | 0.4606 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0097 | 0.4606 | 0.4606 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0087 | 0.3699 | 0.3699 |
Brugia malayi | ORL1-like opioid receptor | 0.0049 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0049 | 0 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0049 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0087 | 0.3699 | 0.3699 |
Brugia malayi | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0049 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0049 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | M-1 s-1 | Inhibition of Cathepsin B (fluorogenic assay); not determined | ChEMBL. | No reference |
k obs / 1 (binding) | = 8000 M-1 s-1 | Apparent second order rate constant for inhibition of calpain-1 by fluorogenic assay. | ChEMBL. | No reference |
k obs / 1 (binding) | = 8000 M-1 s-1 | Apparent second order rate constant for inhibition of calpain-1 by fluorogenic assay. | ChEMBL. | No reference |
ND (binding) | 0 M-1 s-1 | Inhibition of Cathepsin B (fluorogenic assay); not determined | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.