Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0164 | 0.4883 | 0.4883 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0122 | 0.231 | 0.154 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0248 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0122 | 0.231 | 0.231 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0103 | 0.1126 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0122 | 0.231 | 0.231 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0103 | 0.1126 | 0.5 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0103 | 0.1126 | 0.1126 |
Schistosoma mansoni | glutamate receptor kainate | 0.0229 | 0.8816 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0122 | 0.231 | 0.231 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0164 | 0.4883 | 0.4883 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0122 | 0.231 | 0.231 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0103 | 0.1126 | 0.5 |
Echinococcus multilocularis | NMDA receptor | 0.0164 | 0.4883 | 0.4883 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0248 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0248 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0103 | 0.1126 | 0.1126 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0248 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0164 | 0.4883 | 0.4883 |
Schistosoma mansoni | glutamate receptor kainate | 0.0229 | 0.8816 | 1 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0164 | 0.4883 | 0.4883 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0103 | 0.1126 | 0.1126 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0248 | 1 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0103 | 0.1126 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 10000 nM | Tested for cytotoxic concentration on HIV-I Lai wild type in CEM-SS cell line | ChEMBL. | 11052800 |
CC50 (functional) | > 10000 nM | Tested for cytotoxic concentration on HIV-I Lai wild type in CEM-SS cell line | ChEMBL. | 11052800 |
IC50 (functional) | = 460 nM | Tested for inhibitory concentration on HIV-I Lai wild type in CEM-SS cell line | ChEMBL. | 11052800 |
IC50 (functional) | = 460 nM | Tested for inhibitory concentration on HIV-I Lai wild type in CEM-SS cell line | ChEMBL. | 11052800 |
SI (functional) | > 21 | Selectivity index is the ratio of CC50 to IC50 | ChEMBL. | 11052800 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 11052800 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.