Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0138 | 0.0632 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0138 | 0.0632 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0138 | 0.0632 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0917 | 0.9739 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0138 | 0.0632 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0623 | 0.6307 | 0.6306 |
Loa Loa (eye worm) | hypothetical protein | 0.0856 | 0.9025 | 0.9024 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0083 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0138 | 0.0632 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0601 | 0.6046 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0138 | 0.0632 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0083 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0138 | 0.0632 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Percentage inhibition was measured on human placenta dipeptidylpeptidase 4 after 2 min incubation | ChEMBL. | 7966157 |
Inhibition (binding) | = 0 % | Percentage inhibition of the compound was measured on human placenta dipeptidylpeptidase 4 after 30 min | ChEMBL. | 7966157 |
K obs / 1 (binding) | = 1.7 M-1 s-1 | The second order inhibition rate constant was measured against human placenta dipeptidylpeptidase 4 | ChEMBL. | 7966157 |
T1/2 (ADMET) | = 52 hr | Half life for the spontaneous hydrolysis in buffer was measured | ChEMBL. | 7966157 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.