Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0153 | 0.372 | 0.3643 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0101 | 0.1794 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.017 | 0.4357 | 1 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.0101 | 0.1794 | 0.5 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.0101 | 0.1794 | 0.1694 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.0101 | 0.1794 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0135 | 0.3047 | 0.7585 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0153 | 0.372 | 0.2347 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0101 | 0.1794 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0135 | 0.3047 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.3446 | 1 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.0101 | 0.1794 | 0.5 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.0101 | 0.1794 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.3446 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0146 | 0.3446 | 1 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.0101 | 0.1794 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0323 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0153 | 0.372 | 0.2347 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.3047 | 0.7585 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0323 | 1 | 1 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.0101 | 0.1794 | 0.1694 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0323 | 1 | 1 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.0101 | 0.1794 | 0.5 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0101 | 0.1794 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.017 | 0.4357 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.29 | Inhibitory activity of the compound against 3' processing by HIV integrase | ChEMBL. | 14711310 |
IC50 (binding) | = 4.32 | Inhibitory activity of the compound against DNA strand transfer by HIV integrase | ChEMBL. | 14711310 |
Log IC50 (binding) | = 4.29 | Inhibitory activity of the compound against 3' processing by HIV integrase | ChEMBL. | 14711310 |
Log IC50 (binding) | = 4.32 | Inhibitory activity of the compound against DNA strand transfer by HIV integrase | ChEMBL. | 14711310 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.