Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | jun proto-oncogene | Starlite/ChEMBL | References |
Homo sapiens | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Starlite/ChEMBL | References |
Homo sapiens | v-rel avian reticuloendotheliosis viral oncogene homolog A | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | jun protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Brugia malayi | bZIP transcription factor family protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Echinococcus granulosus | jun protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.3258 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0101 | 0.337 | 1 |
Echinococcus granulosus | jun protein | 0.0101 | 0.337 | 0.337 |
Echinococcus multilocularis | jun protein | 0.0101 | 0.337 | 0.337 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0101 | 0.337 | 0.337 |
Schistosoma mansoni | jun-related protein | 0.0082 | 0.2608 | 1 |
Echinococcus granulosus | Ankyrin | 0.0018 | 0.0006 | 0.0006 |
Onchocerca volvulus | 0.008 | 0.2497 | 0.5 | |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0267 | 1 | 1 |
Echinococcus multilocularis | Ankyrin | 0.0018 | 0.0006 | 0.0006 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.2608 | 1 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0018 | 0.0006 | 0.0023 |
Brugia malayi | hypothetical protein | 0.008 | 0.2497 | 0.7409 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0101 | 0.337 | 0.337 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.6 uM | Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells | ChEMBL. | 11052805 |
IC50 (binding) | = 0.6 uM | Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cells | ChEMBL. | 11052805 |
IC50 (binding) | = 0.8 uM | Concentration required to inhibit nuclear factor-kappa B) mediated transcriptional activation in human Jurkat T-cells. | ChEMBL. | 11052805 |
IC50 (binding) | = 0.8 uM | Concentration required to inhibit nuclear factor-kappa B) mediated transcriptional activation in human Jurkat T-cells. | ChEMBL. | 11052805 |
Permeability (ADMET) | = 0.0000009 cm s-1 | Compound was tested for permeability in Caco-2 cells by HPLC method | ChEMBL. | 11052805 |
Permeability (ADMET) | = 0.0000009 cm s-1 | Compound was tested for permeability in Caco-2 cells by HPLC method | ChEMBL. | 11052805 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.