Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0028 | 0.0347 | 0.0539 |
Schistosoma mansoni | thyroid hormone receptor | 0.011 | 0.5517 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0096 | 0.4667 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0096 | 0.4667 | 0.8445 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0023 | 0.0053 | 0.0113 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0023 | 0.0053 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0347 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0347 | 0.0539 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0347 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0347 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0096 | 0.4667 | 0.8445 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0028 | 0.0347 | 0.0539 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0028 | 0.0347 | 0.0744 |
Schistosoma mansoni | thyroid hormone receptor | 0.011 | 0.5517 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0159 | 0.8618 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0347 | 0.0344 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.011 | 0.5517 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0023 | 0.0053 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0347 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0181 | 1 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0159 | 0.8618 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 5 % | Displacement of specific [3H]-CGS-21,680 binding in rat striatal membrane (Adenosine A2A receptor) at concentration of 10 mM. | ChEMBL. | 9767636 |
Displacement (binding) | = 5 % | Displacement of specific [3H]-CGS-21,680 binding in rat striatal membrane (Adenosine A2A receptor) at concentration of 10 mM. | ChEMBL. | 9767636 |
Ki (binding) | = 0.37 mM | Displacement of specific [125I]-AB-MECA binding at human adenosine A3 receptor expressed in HEK 293 cells. | ChEMBL. | 9767636 |
Ki (binding) | = 0.37 mM | Displacement of specific [125I]-AB-MECA binding at human adenosine A3 receptor expressed in HEK 293 cells. | ChEMBL. | 9767636 |
Ki (binding) | = 0.7 mM | Displacement of [3H]-DPCPX from Adenosine A1 receptor of rat cortical membrane | ChEMBL. | 9767636 |
Ki (binding) | = 0.7 mM | Displacement of [3H]-DPCPX from Adenosine A1 receptor of rat cortical membrane | ChEMBL. | 9767636 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.