Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutathione reductase | 0.0143 | 0.6927 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.5922 | 0.855 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.5922 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.5922 | 0.855 |
Brugia malayi | glutathione reductase | 0.0143 | 0.6927 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 1 |
Onchocerca volvulus | 0.013 | 0.5922 | 0.5 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0062 | 0.068 | 0.0981 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.068 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0143 | 0.6927 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0143 | 0.6927 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0143 | 0.6927 | 0.6703 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.5922 | 0.855 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.5922 | 0.855 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0053 | 0 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0143 | 0.6927 | 1 |
Brugia malayi | thymidylate synthase | 0.013 | 0.5922 | 0.855 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0143 | 0.6927 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0143 | 0.6927 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0062 | 0.068 | 0.0981 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.5922 | 0.855 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.5922 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.