Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | oxidoreductase | 0.0152 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0152 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0152 | 1 | 0.5 |
Onchocerca volvulus | 0.0152 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase | 0.0152 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0152 | 1 | 0.5 |
Leishmania major | prostaglandin f synthase, putative | 0.0152 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0152 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0152 | 1 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0152 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0152 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0152 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0152 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0152 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0152 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0152 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0152 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0152 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0152 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0152 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0152 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0152 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0152 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0152 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0152 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0152 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0152 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0152 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0152 | 1 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0152 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0152 | 1 | 0.5 |
Onchocerca volvulus | 0.0152 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0152 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0152 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0152 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0152 | 1 | 0.5 |
Onchocerca volvulus | 0.0152 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0152 | 1 | 0.5 |
Onchocerca volvulus | 0.0152 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase | 0.0152 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0152 | 1 | 0.5 |
Schistosoma mansoni | pol-related | 0.0152 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0152 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0152 | 1 | 1 |
Onchocerca volvulus | 0.0152 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0152 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0152 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0152 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0152 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0152 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0152 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0152 | 1 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0152 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0152 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0152 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0152 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0152 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0152 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0152 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0152 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0152 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0152 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0152 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0152 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0152 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0152 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0152 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0152 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0152 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0152 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0152 | 1 | 0.5 |
Onchocerca volvulus | 0.0152 | 1 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0152 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0152 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0152 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0152 | 1 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0152 | 1 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0152 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0152 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log IC50 (functional) | = 6 | Tested in vitro for bronchodilatory activity by spontaneous tone inhibition in guinea pig tracheal strips | ChEMBL. | 8258827 |
Inhibition (functional) | = 37 % | Tested for inhibition of thromboxane A2 (TXA2) production in rat serum by ex vivo assay after peroral dose of 30 mg/kg | ChEMBL. | 8258827 |
Inhibition (functional) | = 37 % | Tested for inhibition of thromboxane A2 (TXA2) production in rat serum by ex vivo assay after peroral dose of 30 mg/kg | ChEMBL. | 8258827 |
Inhibition (functional) | = 42 % | In vivo inhibitory effect on airway constriction induced by histamine 2-5 micro g/kg iv at 1 min after 10 mg/kg intravenous dose in anesthetized guinea pigs | ChEMBL. | 8258827 |
Inhibition (binding) | = 49 % | Tested for inhibition of thromboxane A2 (TXA2) production in rabbit by in vitro assay at 1 microM | ChEMBL. | 8258827 |
Inhibition (binding) | = 49 % | Tested for inhibition of thromboxane A2 (TXA2) production in rabbit by in vitro assay at 1 microM | ChEMBL. | 8258827 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.