Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | peptide deformylase, putative | 0.1144 | 1 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0437 | 0 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0437 | 0 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.1144 | 1 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0437 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0437 | 0 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0437 | 0 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0437 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0437 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1144 | 1 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.1144 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.1144 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.1144 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.1144 | 1 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.1144 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 8.6 mg kg-1 | In vivo antibacterial activity in a murine systemic infection model | ChEMBL. | 12190317 |
ED50 (functional) | = 8.6 mg kg-1 | In vivo antibacterial activity in a murine systemic infection model | ChEMBL. | 12190317 |
MIC (functional) | = 1 ug ml-1 | In vitro antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 33591 (S. a. 019) | ChEMBL. | 12190317 |
MIC (functional) | = 2 ug ml-1 | In vitro antibacterial activity against Staphylococcus aureus ATCC 49951 (S. a. 213) | ChEMBL. | 12190317 |
MIC (functional) | = 2 ug ml-1 | In vitro antibacterial activity against Staphylococcus aureus ATCC 29213 (S. a. 035) | ChEMBL. | 12190317 |
MIC (functional) | = 2 ug ml-1 | In vitro antibacterial activity against Enterococcus faecalis ATCC 29212 (E. f. 034) vancomycin sensitive | ChEMBL. | 12190317 |
MIC (functional) | = 2 ug ml-1 | In vitro antibacterial activity against Enterococcus faecalis NCTC 12201 (E. f. 153) vancomycin resistant | ChEMBL. | 12190317 |
MIC (functional) | = 4 ug ml-1 | In vitro antibacterial activity against Enterococcus faecium ATCC 12202 (E.fm 154) vancomycin resistant | ChEMBL. | 12190317 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.