Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.0971 | 0.6602 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0362 | 0.6743 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0122 | 0.1975 | 0.1975 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0045 | 0.0432 | 0.346 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0086 | 0.1248 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0526 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0045 | 0.0432 | 0.346 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0086 | 0.1248 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0042 | 0.037 | 0.0744 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0171 | 0.2939 | 0.262 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0086 | 0.1248 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0171 | 0.2939 | 0.2939 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0107 | 0.1678 | 0.1303 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0086 | 0.1248 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0072 | 0.0971 | 0.7778 |
Treponema pallidum | polypeptide deformylase (def) | 0.0225 | 0.4009 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.0971 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0225 | 0.4009 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0069 | 0.0919 | 0.0509 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.0971 | 1 |
Mycobacterium leprae | Isocitrate lyase | 0.0247 | 0.4446 | 0.0728 |
Mycobacterium ulcerans | peptide deformylase | 0.0225 | 0.4009 | 0.3739 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0171 | 0.2939 | 0.262 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (small chain) | 0.0069 | 0.0919 | 0.0919 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.0971 | 0.6602 |
Echinococcus granulosus | dna polymerase kappa | 0.0045 | 0.0432 | 0.1694 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0526 | 1 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0362 | 0.6743 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0526 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.0971 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Plasmodium vivax | peptide deformylase, putative | 0.0225 | 0.4009 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0086 | 0.1248 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0037 | 0.0289 | 0.2319 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0086 | 0.1248 | 1 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0526 | 1 | 1 |
Treponema pallidum | quinoline 2-oxidoreductase | 0.0057 | 0.0688 | 0.0512 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0072 | 0.0971 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0042 | 0.037 | 0.0744 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Treponema pallidum | hypothetical protein | 0.0059 | 0.0715 | 0.059 |
Echinococcus multilocularis | dna polymerase kappa | 0.0045 | 0.0432 | 0.1694 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0122 | 0.1975 | 0.1613 |
Toxoplasma gondii | hypothetical protein | 0.0225 | 0.4009 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0322 | 0.1401 |
Mycobacterium ulcerans | hypothetical protein | 0.0059 | 0.0715 | 0.0296 |
Trypanosoma brucei | unspecified product | 0.0037 | 0.0289 | 0.2319 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.0216 | 0.1733 |
Plasmodium falciparum | peptide deformylase | 0.0225 | 0.4009 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.0971 | 0.7778 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0072 | 0.0971 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0225 | 0.4009 | 0.4009 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0069 | 0.0919 | 0.0509 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.0216 | 0.1733 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0662 | 0.5241 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.024 | 0.4313 | 0.4056 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0362 | 0.6743 | 1 |
Chlamydia trachomatis | peptide deformylase | 0.0225 | 0.4009 | 0.5 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0526 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0122 | 0.1975 | 0.1613 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0086 | 0.1248 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.0971 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 47 % | In vitro inhibition of collagen-induced platelet aggregation in human platelet-rich plasma (PRP) at 273 uM | ChEMBL. | 8831771 |
Inhibition (functional) | = 47 % | In vitro inhibition of collagen-induced platelet aggregation in human platelet-rich plasma (PRP) at 273 uM | ChEMBL. | 8831771 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.