Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0125 | 0.0408 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Echinococcus multilocularis | dna polymerase kappa | 0.0046 | 0.0681 | 0.516 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Echinococcus granulosus | dna polymerase kappa | 0.0046 | 0.0681 | 0.516 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0046 | 0.0681 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0024 | 0.0227 | 0.0151 |
Trypanosoma brucei | unspecified product | 0.0039 | 0.0531 | 0.3879 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0074 | 0.1247 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0043 | 0.0616 | 0.4606 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0507 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0074 | 0.1247 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0125 | 0.0408 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0507 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0507 | 1 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0074 | 0.1247 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0074 | 0.1247 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0125 | 0.0408 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Brugia malayi | polk-prov protein | 0.0035 | 0.0454 | 0.3223 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0507 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0923 | 0.7227 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0039 | 0.0531 | 0.3879 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0074 | 0.1247 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0454 | 0.3223 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0565 | 0.4172 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.1247 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0012 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0565 | 0.4172 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.1247 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0035 | 0.0454 | 0.3223 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0043 | 0.0616 | 0.4606 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0507 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0024 | 0.0227 | 0.128 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.1247 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0565 | 0.4172 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0046 | 0.0681 | 0.516 |
Giardia lamblia | DINP protein human, muc B family | 0.0024 | 0.0227 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0046 | 0.0681 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0035 | 0.0454 | 0.3223 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0074 | 0.1247 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0046 | 0.0681 | 0.516 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0024 | 0.0227 | 0.128 |
Leishmania major | DNA polymerase kappa, putative | 0.0024 | 0.0227 | 0.128 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0074 | 0.1247 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.11 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.11 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.13 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.13 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.13 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.13 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 18 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 18 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 22 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 22 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 28 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 28 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 28 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 28 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Blockade of morphine-induced elevation of tail-flick latency | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Blockade of morphine-induced elevation of tail-flick latency | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.