Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thromboxane A2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Fibulin-1 precursor | 0.0084 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0084 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0084 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0084 | 0.5 | 0.5 |
Echinococcus multilocularis | laminin | 0.0084 | 0.5 | 0.5 |
Echinococcus granulosus | laminin | 0.0084 | 0.5 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0084 | 0.5 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0084 | 0.5 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0084 | 0.5 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0084 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.5 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0084 | 0.5 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0084 | 0.5 | 0.5 |
Schistosoma mansoni | egf-like domain protein | 0.0084 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.5 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.0084 | 0.5 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0084 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 71 uM | Inhibition of collagen-induced platelet aggregation in human platelet rich plasma | ChEMBL. | 8831771 |
EC50 (functional) | = 71 uM | Inhibition of collagen-induced platelet aggregation in human platelet rich plasma | ChEMBL. | 8831771 |
IC50 (functional) | = 2.5 uM | TXA2 receptor antagonism, measured by the displacement of [3H]SQ29,548 from the PGH-2/TXA-2 receptor on human platelets | ChEMBL. | 8831771 |
IC50 (functional) | = 2.5 uM | TXA2 receptor antagonism, measured by the displacement of [3H]SQ29,548 from the PGH-2/TXA-2 receptor on human platelets | ChEMBL. | 8831771 |
IC50 (binding) | > 100 uM | TXA2 synthetase inhibition measured by the inhibition of TXB2 formation by human gel-filtered platelets incubated with [14C]-arachidonic acid | ChEMBL. | 8831771 |
IC50 (binding) | > 100 uM | TXA2 synthetase inhibition measured by the inhibition of TXB2 formation by human gel-filtered platelets incubated with [14C]-arachidonic acid | ChEMBL. | 8831771 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.