Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor NMDA | 0.0177 | 0.1866 | 0.1866 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0238 | 0.5319 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0198 | 0.3037 | 0.1439 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0321 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0198 | 0.3037 | 0.3037 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 9 mg kg-1 | Effective dose required for analgesic activity by trypsin-induced hyperalgesia assay at 20 mg/kg by oral administration in rats | ChEMBL. | 12540239 |
ED50 (functional) | = 31 mg kg-1 | Effective dose required for muscle relaxation by intraperitoneal administration in mouse using Straub-tail (ST) assay | ChEMBL. | 12540239 |
ED50 (functional) | = 31 mg kg-1 | Effective dose required for muscle relaxation by intraperitoneal administration in mouse using Straub-tail (ST) assay | ChEMBL. | 12540239 |
ED50 (functional) | = 44 mg kg-1 | Effective dose required for muscle relaxation by intraperitoneal administration in mouse using Straub-tail (ST) assay | ChEMBL. | 12540239 |
ED50 (functional) | = 108 mg kg-1 | Effective dose required for muscle relaxation by oral administration in mouse using Straub-tail (ST) assay. | ChEMBL. | 12540239 |
ED50 (functional) | = 108 mg kg-1 | Effective dose required for muscle relaxation by oral administration in mouse using Straub-tail (ST) assay. | ChEMBL. | 12540239 |
ED50 (functional) | = 164 mg kg-1 | Sedation caused by oral administration was estimated using rotorod (RR) assay. | ChEMBL. | 12540239 |
ED50 (functional) | = 164 mg kg-1 | Sedation caused by oral administration was estimated using rotorod (RR) assay. | ChEMBL. | 12540239 |
Inhibition (functional) | = 88 % | Percent inhibition for analgesic activity by trypsin-induced hyperalgesia assay at 20 mg/kg by oral administration in rats. | ChEMBL. | 12540239 |
ND (functional) | 0 | Effective dose required for muscle relaxation by oral administration in mouse using Straub-tail (ST) assay. | ChEMBL. | 12540239 |
ND (functional) | 0 | Sedation by oral administration was estimated using rotorod (RR) assay. | ChEMBL. | 12540239 |
ND (functional) | 0 | Ratio of rotorod to straub tail activity, which indicates the dose exhibiting muscle relaxant activity versus that producing sedation. | ChEMBL. | 12540239 |
ND (functional) | 0 | Antiinflammatory activity in cells by Carragenaan pleurisy assay by oral administration. | ChEMBL. | 12540239 |
ND (functional) | 0 | Antiinflammatory activity in edema by Carragenaan pleurisy assay by oral administration. | ChEMBL. | 12540239 |
ND (functional) | 0 | Percent inhibition for analgesic activity by trypsin-induced hyperalgesia assay at 20 mg/kg by oral administration in rats; ND is no data. | ChEMBL. | 12540239 |
ND (functional) | 0 | Effective dose required for analgesic activity by trypsin-induced hyperalgesia assay at 20 mg/kg by oral administration in rats. | ChEMBL. | 12540239 |
ND (functional) | 0 | Antiinflammatory activity of the compound in cells by Carragenaan pleurisy assay by oral administration; ND means no data | ChEMBL. | 12540239 |
ND (functional) | 0 | Antiinflammatory activity of the compound in edema by Carragenaan pleurisy assay by oral administration; ND means no data | ChEMBL. | 12540239 |
Ratio (functional) | = 1.5 | Ratio of rotorod to straub tail activity, which indicates the dose exhibiting muscle relaxant activity versus that producing sedation | ChEMBL. | 12540239 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.