Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0061 | 0.4332 | 0.389 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0034 | 0.1404 | 0.1279 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0034 | 0.1404 | 0.1279 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0027 | 0.0723 | 0.0588 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0027 | 0.0723 | 1 |
Brugia malayi | hypothetical protein | 0.0034 | 0.1404 | 0.1404 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0027 | 0.0723 | 0.46 |
Brugia malayi | flavodoxin family protein | 0.0027 | 0.0723 | 0.0723 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0034 | 0.1404 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0034 | 0.1404 | 0.0734 |
Trypanosoma cruzi | p450 reductase, putative | 0.0027 | 0.0723 | 0.46 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0034 | 0.1404 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0041 | 0.215 | 0.246 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0034 | 0.1404 | 0.0734 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0093 | 0.7675 | 0.8782 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0027 | 0.0723 | 0.3266 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0034 | 0.1404 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0034 | 0.1404 | 0.1404 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0024 | 0.0393 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0034 | 0.1404 | 0.6533 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0027 | 0.0723 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0027 | 0.0723 | 0.0588 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0034 | 0.1404 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0034 | 0.1404 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0115 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0024 | 0.0393 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.8739 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0115 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0061 | 0.4332 | 0.425 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0027 | 0.0723 | 0.3266 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0034 | 0.1404 | 0.1279 |
Brugia malayi | Matrixin family protein | 0.0041 | 0.215 | 0.215 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0027 | 0.0723 | 0.46 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0034 | 0.1404 | 0.1279 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0034 | 0.1404 | 0.0734 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0034 | 0.1404 | 1 |
Loa Loa (eye worm) | aminopeptidase N | 0.0034 | 0.1404 | 0.1606 |
Onchocerca volvulus | Matrilysin homolog | 0.0037 | 0.1792 | 0.1487 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0037 | 0.1792 | 0.1487 |
Brugia malayi | Hemopexin family protein | 0.0024 | 0.0358 | 0.0358 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0034 | 0.1404 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0034 | 0.1404 | 1 |
Leishmania major | p450 reductase, putative | 0.0027 | 0.0723 | 0.3266 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0027 | 0.0723 | 0.3005 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0143 | 0.0164 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0034 | 0.1404 | 0.1279 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0027 | 0.0723 | 0.46 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.004 | 0.2073 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0034 | 0.1404 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0027 | 0.0723 | 0.515 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0034 | 0.1404 | 0.6533 |
Onchocerca volvulus | 0.0115 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0723 | 0.0827 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0034 | 0.1404 | 0.1279 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0034 | 0.1404 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0034 | 0.1404 | 0.0734 |
Onchocerca volvulus | 0.0034 | 0.1404 | 0.1084 | |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0021 | 0 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0027 | 0.0723 | 0.0723 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0034 | 0.1404 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.6414 | 0.7339 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0037 | 0.1792 | 0.205 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0034 | 0.1404 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0027 | 0.0723 | 0.0827 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0143 | 0.0164 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0358 | 0.1115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.