Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.1596 | 0.8469 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1184 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.1764 | 0.9357 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1184 | 1 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0462 | 0.3763 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0462 | 0.3763 | 0.3763 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1184 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0462 | 0.3763 | 1 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0238 | 0.1828 | 0.4858 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0462 | 0.3763 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0245 | 0.1885 | 0.1885 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1184 | 1 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.0094 | 0.0251 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0238 | 0.1828 | 0.4858 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0094 | 0.0094 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0462 | 0.3763 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0462 | 0.3763 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0462 | 0.3763 | 0.3763 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0094 | 0.0251 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0094 | 0.0094 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0462 | 0.3763 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1184 | 1 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0094 | 0.0094 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.0094 | 0.0251 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0462 | 0.3763 | 1 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0238 | 0.1828 | 0.1828 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1184 | 1 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0094 | 0.0094 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.0094 | 0.0251 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0462 | 0.3763 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.0094 | 0.0501 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0462 | 0.3763 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1184 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0094 | 0.0251 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0094 | 0.0094 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0094 | 0.0094 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1184 | 1 | 1 |
Brugia malayi | Inositol-1 | 0.0038 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0245 | 0.1885 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0462 | 0.3763 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.1184 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1184 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0462 | 0.3763 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1184 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1184 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1184 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1184 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log Ki (binding) | = 2.7 mM | Inhibitory activity against rabbit muscle glycogen phosphorylase | ChEMBL. | 9406599 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.