Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Liver glycogen phosphorylase | Starlite/ChEMBL | References |
Homo sapiens | phosphorylase, glycogen | Starlite/ChEMBL | References |
Mus musculus | liver glycogen phosphorylase | Starlite/ChEMBL | References |
Homo sapiens | phosphorylase, glycogen, liver | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glycogen phosphorylase | 0.0522 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0522 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0522 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0522 | 0.5 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0522 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0522 | 0.5 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0522 | 0.5 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0522 | 0.5 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0522 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0522 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0522 | 0.5 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0522 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0522 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0522 | 0.5 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0522 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0522 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 207 nM | Inhibitory activity against mouse liver glycogen phosphorylase | ChEMBL. | 14592521 |
IC50 (binding) | = 207 nM | Inhibitory activity against mouse liver glycogen phosphorylase | ChEMBL. | 14592521 |
IC50 (binding) | = 250 nM | Inhibitory activity against HLGP(human liver glycogen phosphorylase) | ChEMBL. | 14592521 |
IC50 (binding) | = 250 nM | Inhibitory activity against HLGP(human liver glycogen phosphorylase) | ChEMBL. | 14592521 |
IC50 (binding) | = 302 nM | Inhibitory activity against rat liver glycogen phosphorylase | ChEMBL. | 14592521 |
IC50 (binding) | = 302 nM | Inhibitory activity against rat liver glycogen phosphorylase | ChEMBL. | 14592521 |
IC50 (binding) | = 1860 nM | Inhibitory activity against HMGP(human muscle glycogen phosphorylase) | ChEMBL. | 14592521 |
IC50 (binding) | = 1860 nM | Inhibitory activity against HMGP(human muscle glycogen phosphorylase) | ChEMBL. | 14592521 |
Ratio (binding) | = 7 | Ratio of HMGP to that of HLGP was determined | ChEMBL. | 14592521 |
Ratio (binding) | = 7 | Ratio of HMGP to that of HLGP was determined | ChEMBL. | 14592521 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.