Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lipoxygenase | 0.0253 | 1 | 1 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.024 | 0.8299 | 0.8299 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0253 | 1 | 1 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.024 | 0.8299 | 0.8299 |
Toxoplasma gondii | MAPEG family protein | 0.024 | 0.8299 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | NT 0 mg kg-1 | Tested for the antimicrobial activity against Escherichia coli in mice | ChEMBL. | 7381838 |
ED50 (functional) | NT 0 mg kg-1 | Tested for the antimicrobial activity against Salmonella schottmuelleri in mice, subcutaneously; NT means compound was not tested. | ChEMBL. | 7381838 |
ED50 (functional) | = 0.5 mg kg-1 | Tested for the antimicrobial activity against Staphylococcus aureus, benzylpenicillin sensitive in mice, perorally | ChEMBL. | 7381838 |
ED50 (functional) | = 0.81 mg kg-1 | Tested for the antimicrobial activity against Streptococcus pyogenes in mice | ChEMBL. | 7381838 |
ED50 (functional) | = 1 mg kg-1 | Tested for the antimicrobial activity against Streptococcus pyogenes in mice | ChEMBL. | 7381838 |
ED50 (functional) | = 1.5 mg kg-1 | Tested for the antimicrobial activity against Staphylococcus aureus | ChEMBL. | 7381838 |
ED50 (functional) | = 8.3 mg kg-1 | Tested for the antimicrobial activity against Staphylococcus aureus, benzylpenicillin resistant in mice, perorally | ChEMBL. | 7381838 |
ED50 (functional) | = 14 mg kg-1 | Tested for the antimicrobial activity against Streptococcus pneumoniae in mice | ChEMBL. | 7381838 |
ED50 (functional) | = 15 mg kg-1 | Tested for the antimicrobial activity against Streptococcus pneumoniae in mice | ChEMBL. | 7381838 |
MIC (functional) | = 0.4 ug ml-1 | Tested for inhibition of visible growth of Streptococcus pyogenes | ChEMBL. | 7381838 |
MIC (functional) | = 0.8 ug ml-1 | Tested for inhibition of visible growth of Staphylococcus aureus, benzylpenicillin sensitive | ChEMBL. | 7381838 |
MIC (functional) | = 0.8 ug ml-1 | Tested for inhibition of visible growth of Streptococcus pyogenes | ChEMBL. | 7381838 |
MIC (functional) | = 0.8 ug ml-1 | Tested for inhibition of visible growth of Streptococcus pneumoniae | ChEMBL. | 7381838 |
MIC (functional) | = 1.6 ug ml-1 | Tested for inhibition of visible growth of Streptococcus pneumoniae | ChEMBL. | 7381838 |
MIC (functional) | = 3.1 ug ml-1 | Tested for inhibition of visible growth of Staphylococcus aureus | ChEMBL. | 7381838 |
MIC (functional) | = 6.2 ug ml-1 | Tested for inhibition of visible growth of Staphylococcus aureus | ChEMBL. | 7381838 |
MIC (functional) | = 50 ug ml-1 | Tested for inhibition of visible growth of Salmonella schottmuelleri | ChEMBL. | 7381838 |
MIC (functional) | = 100 ug ml-1 | Tested for inhibition of visible growth of Salmonella schottmuelleri | ChEMBL. | 7381838 |
MIC (functional) | > 100 ug ml-1 | Tested for inhibition of visible growth of Streptococcus faecalis | ChEMBL. | 7381838 |
MIC (functional) | > 100 ug ml-1 | Tested for inhibition of visible growth of Enterobacter aerogenes | ChEMBL. | 7381838 |
MIC (functional) | > 100 ug ml-1 | Tested for inhibition of visible growth of Enterobacter cloacae | ChEMBL. | 7381838 |
MIC (functional) | > 100 ug ml-1 | Tested for inhibition of visible growth of Escherichia coli | ChEMBL. | 7381838 |
MIC (functional) | = 100 ug ml-1 | Tested for inhibition of visible growth of Klebsiella pneumoniae | ChEMBL. | 7381838 |
MIC (functional) | > 100 ug ml-1 | Tested for inhibition of visible growth of Proteus mirabilis | ChEMBL. | 7381838 |
MIC (functional) | > 200 ug ml-1 | Tested for inhibition of visible growth of Streptococcus faecalis | ChEMBL. | 7381838 |
MIC (functional) | > 200 ug ml-1 | Tested for inhibition of visible growth of Enterobacter aerogenes | ChEMBL. | 7381838 |
MIC (functional) | > 200 ug ml-1 | Tested for inhibition of visible growth of Enterobacter cloacae | ChEMBL. | 7381838 |
MIC (functional) | = 200 ug ml-1 | Tested for inhibition of visible growth of Escherichia coli | ChEMBL. | 7381838 |
MIC (functional) | = 200 ug ml-1 | Tested for inhibition of visible growth of Klebsiella pneumoniae | ChEMBL. | 7381838 |
MIC (functional) | > 200 ug ml-1 | Tested for inhibition of visible growth of Proteus mirabilis | ChEMBL. | 7381838 |
MIC (functional) | = 200 ug ml-1 | Tested for inhibition of visible growth of Escherichia coli | ChEMBL. | 7381838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.