Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1707 | 0.5 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.1707 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1707 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 11 mg kg-1 | Antiinflammatory activity in edema by Carragenaan pleurisy assay by oral administration | ChEMBL. | 12540239 |
ED50 (functional) | = 14 mg kg-1 | Antiinflammatory activity in cells using Carragenaan pleurisy assay by oral administration | ChEMBL. | 12540239 |
Inhibition (functional) | = 0 % | Percent effect profile muscle relaxation at 100 mg/kg by intraperitoneal administration in mouse using Straub-tail (ST) assay | ChEMBL. | 12540239 |
Inhibition (functional) | = 0 % | Percent effect profile muscle relaxation at 100 mg/kg by intraperitoneal administration in mouse using Straub-tail (ST) assay | ChEMBL. | 12540239 |
Inhibition (functional) | = 6 % | Percent inhibition for analgesic activity by trypsin-induced hyperalgesia assay at 20 mg/kg by oral administration in rats | ChEMBL. | 12540239 |
ND (functional) | 0 | Effective dose required for muscle relaxation by oral administration in mouse using Straub-tail (ST) assay; ND means no data | ChEMBL. | 12540239 |
ND (functional) | 0 | Sedation caused by the compound by oral administration was estimated using rotorod (RR) assay; ND means no data | ChEMBL. | 12540239 |
ND (functional) | 0 | Ratio of rotorod to straub tail activity, which indicates the dose exhibiting muscle relaxant activity versus that producing sedation; ND means no data | ChEMBL. | 12540239 |
ND (functional) | 0 | Effective dose required for analgesic activity by trypsin-induced hyperalgesia assay at 20 mg/kg by oral administration in rats; ND means no data | ChEMBL. | 12540239 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.