Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0753 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0753 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0753 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0753 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0753 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0753 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0753 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0753 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0753 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0753 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0465 | 0.2407 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0753 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0374 | 0 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0753 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0667 | 0.7743 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0753 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0753 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0465 | 0.2407 | 0.2407 |
Loa Loa (eye worm) | hypothetical protein | 0.0753 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0753 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0753 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0753 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0753 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0753 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0667 | 0.7743 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0374 | 0 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0379 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0753 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0753 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 ratio (binding) | = 1.65 | Inhibition of ethylketazocine binding to Opioid receptor kappa 1 of guinea pig ileal longitudinal muscle | ChEMBL. | 9767654 |
IC50 ratio (binding) | = 3.86 | Inhibition of morphine binding to Opioid receptor mu 1 of guinea pig ileal longitudinal muscle | ChEMBL. | 9767654 |
IC50 ratio (binding) | = 17 | Inhibition of DADLE binding to Opioid receptor delta 1 of mouse vas deferens | ChEMBL. | 9767654 |
IC50 ratio (binding) | = 1.65 | Inhibition of ethylketazocine binding to Opioid receptor kappa 1 of guinea pig ileal longitudinal muscle | ChEMBL. | 9767654 |
IC50 ratio (binding) | = 3.86 | Inhibition of morphine binding to Opioid receptor mu 1 of guinea pig ileal longitudinal muscle | ChEMBL. | 9767654 |
IC50 ratio (binding) | = 17 | Inhibition of DADLE binding to Opioid receptor delta 1 of mouse vas deferens | ChEMBL. | 9767654 |
Selectivity ratio (binding) | = 4.4 | Relative affinity for delta and mu receptors | ChEMBL. | 9767654 |
Selectivity ratio (binding) | = 10.3 | Relative affinity for delta and kappa receptors | ChEMBL. | 9767654 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.