Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.2236 | 0.5 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2236 | 0.5 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2236 | 0.5 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.2236 | 0.5 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.2236 | 0.5 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2236 | 0.5 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.2236 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2236 | 0.5 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2236 | 0.5 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.2236 | 0.5 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2236 | 0.5 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2236 | 0.5 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2236 | 0.5 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.2236 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0.23 | In vivo antibacterial activity against Staphylococcus aureus after intramuscular administration of the compound (5 mg/kg) in mice using (MTT) mouse thigh test | ChEMBL. | 14622997 |
Activity (functional) | = 0.34 | In vivo antibacterial activity against Staphylococcus aureus after intramuscular administration of the compound (10 mg/kg) in mice using (MTT) mouse thigh test | ChEMBL. | 14622997 |
MIC (functional) | = 1 mg l-1 | In vitro minimum inhibitory concentration against Staphylococcus aureus Oxford | ChEMBL. | 14622997 |
MIC (functional) | = 2 mg l-1 | In vitro minimum inhibitory concentration against Staphylococcus aureus MRQR | ChEMBL. | 14622997 |
MIC (functional) | = 2 mg l-1 | In vitro minimum inhibitory concentration against coagulase negative Staphylococcus aureus methicillin resistant (CNSMR) | ChEMBL. | 14622997 |
MIC (functional) | = 4 mg l-1 | In vitro minimum inhibitory concentration against Streptococcus pyogenes penicillin sensitive | ChEMBL. | 14622997 |
MIC (functional) | = 4 mg l-1 | In vitro minimum inhibitory concentration against E. faecalis | ChEMBL. | 14622997 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.