Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3B | References | |
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glutamate receptor 1 precursor | 0.0162 | 0.2622 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0181 | 0.3639 | 0.3639 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0162 | 0.2622 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0181 | 0.3639 | 0.3639 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0181 | 0.3639 | 0.3639 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0181 | 0.3639 | 0.3639 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0184 | 0.3813 | 0.3813 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0181 | 0.3639 | 0.3639 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0181 | 0.3639 | 0.3639 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0296 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0181 | 0.3639 | 0.3639 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0162 | 0.2622 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0296 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0276 | 0.891 | 0.8522 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0184 | 0.3813 | 0.3813 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0162 | 0.2622 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0181 | 0.3639 | 0.3639 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0181 | 0.3639 | 0.3639 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0162 | 0.2622 | 0.2622 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0181 | 0.3639 | 0.3639 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 uM | Binding affinity against glycine binding site of N-methyl-D-aspartate glutamate receptor from rat synaptic plasma membrane(SPM) using [3H]-glycine; NA = No effect | ChEMBL. | 1433216 |
IC50 (binding) | = 0.17 uM | Inhibition of [3H]-1 binding to dextromethorpin binding site of guinea pig microsomal pellet P3 N-methyl-D-aspartate glutamate receptor | ChEMBL. | 1433216 |
IC50 (binding) | = 0.17 uM | Inhibition of [3H]-1 binding to dextromethorpin binding site of guinea pig microsomal pellet P3 N-methyl-D-aspartate glutamate receptor | ChEMBL. | 1433216 |
IC50 (binding) | = 0.44 uM | Binding affinity against dextromethorpin binding site associated with N-methyl-D-aspartate glutamate receptor from guinea pig mitochondrial pellet P2 determined using [3H]-1 as radioligand. | ChEMBL. | 1433216 |
IC50 (binding) | = 0.44 uM | Binding affinity against dextromethorpin binding site associated with N-methyl-D-aspartate glutamate receptor from guinea pig mitochondrial pellet P2 determined using [3H]-1 as radioligand. | ChEMBL. | 1433216 |
IC50 (binding) | = 1.5 uM | Binding affinity against dextromethorpin binding site of N-methyl-D-aspartate glutamate receptor from rat brain using [3H]-1 | ChEMBL. | 1433216 |
IC50 (binding) | = 1.5 uM | Binding affinity against dextromethorpin binding site of N-methyl-D-aspartate glutamate receptor from rat brain using [3H]-1 | ChEMBL. | 1433216 |
Inhibition (binding) | = 60 % | Binding affinity against PCP binding site associated with N-methyl-D-aspartate glutamate receptor from rat synaptic plasma membrane(SPM) determined using [3H]-TCP as radioligand. | ChEMBL. | 1433216 |
Inhibition (binding) | = 60 % | Binding affinity against PCP binding site associated with N-methyl-D-aspartate glutamate receptor from rat synaptic plasma membrane(SPM) determined using [3H]-TCP as radioligand. | ChEMBL. | 1433216 |
Protection (functional) | = 0 % | Anticonvulsant activity in rat supramaximal electroshock (MES) test expressed as % rats protected at a dose of 25-50 mg/kg. | ChEMBL. | 1433216 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.