Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cdc48-like protein, putative | 0.0341 | 0.9326 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0359 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.4584 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0359 | 1 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0341 | 0.9326 | 0.5 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0215 | 0.4742 | 0.0000097958 |
Brugia malayi | vesicle-fusing ATPase | 0.0211 | 0.4584 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0341 | 0.9326 | 0.9287 |
Mycobacterium ulcerans | ATPase | 0.0215 | 0.4742 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0341 | 0.9326 | 0.5 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0341 | 0.9326 | 1 |
Brugia malayi | valosin containing protein | 0.0211 | 0.4584 | 1 |
Trypanosoma brucei | Valosin-containing protein | 0.0341 | 0.9326 | 1 |
Giardia lamblia | AAA family ATPase | 0.0215 | 0.4742 | 0.5 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0341 | 0.9326 | 0.5 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0359 | 1 | 1 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0215 | 0.4742 | 0.5 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0211 | 0.4584 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0149 | 0.232 | 0.1874 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0359 | 1 | 1 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0341 | 0.9326 | 0.5 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0359 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Growth rate (functional) | = 5 uM | Antiproliferative activity in L1210 Murine Leukemia in vitro expressed as Growth rate in the presence of compound | ChEMBL. | 7562946 |
IC50 (binding) | = 0.07 uM | antiviral activity in Human immunodeficiency virus-1 as reverse transcriptase activity in culture supernatant | ChEMBL. | 7562946 |
IC50 (functional) | = 0.22 uM | antiviral activity in Human cytomegalovirus by plaque assay (HCMV) | ChEMBL. | 7562946 |
IC50 (functional) | = 2 uM | Visual cytotoxicity scored on CEM cells at time of HCMV plaque enumeration | ChEMBL. | 7562946 |
IC50 (functional) | = 3 uM | cell growth inhibition was determined in KB cells in quadruplicate assays | ChEMBL. | 7562946 |
IC50 (functional) | = 3.1 uM | Visual cytotoxicity scored on HFF cells at time of HCMV plaque enumeration | ChEMBL. | 7562946 |
IC50 (functional) | = 5 uM | antiproliferative activity in L1210 Murine Leukemia in vitro expressed as concentration required to decrease growth rate to 50% of control | ChEMBL. | 7562946 |
IC50 (functional) | = 8.7 uM | Antiviral activity in Herpes simplex virus-1 assayed by ELISA in quadruplicate wells | ChEMBL. | 7562946 |
IC90 (functional) | = 1.5 uM | antiviral activity in Human cytomegalovirus by plaque assay given as yield | ChEMBL. | 7562946 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.