Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | gastrulation defective protein 1 | 0.0138 | 0.0072 | 0.081 |
Mycobacterium ulcerans | hypothetical protein | 0.5873 | 1 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 19 | 0.0139 | 0.0073 | 0.1184 |
Schistosoma mansoni | integrin alpha-4 | 0.0414 | 0.0549 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.5873 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.0213 | 0.239 |
Loa Loa (eye worm) | integrin beta-2 | 0.0611 | 0.0891 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.0453 | 0.0617 | 1 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0611 | 0.0891 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK8 protein kinase | 0.0139 | 0.0073 | 0.0819 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0251 | 0.0267 | 0.2992 |
Schistosoma mansoni | integrin beta subunit | 0.036 | 0.0456 | 0.831 |
Brugia malayi | Protein kinase domain containing protein | 0.0251 | 0.0267 | 0.2994 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0139 | 0.0073 | 0.1331 |
Echinococcus granulosus | cyclin dependent kinase 19 | 0.0139 | 0.0073 | 0.1184 |
Echinococcus granulosus | integrin beta 2 | 0.0453 | 0.0617 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0139 | 0.0073 | 0.0819 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 4.5 uM | In vitro inhibition of P388 murine leukemia cell (S/ADR) growth | ChEMBL. | 1992142 |
ED50 (functional) | = 4.5 uM | In vitro inhibition of P388 murine leukemia cell (S/ADR) growth | ChEMBL. | 1992142 |
ED50 (functional) | = 8 uM | In vitro inhibition of P388 murine leukemia cell (R/ADR) growth | ChEMBL. | 1992142 |
ED50 (functional) | = 8 uM | In vitro inhibition of P388 murine leukemia cell (R/ADR) growth | ChEMBL. | 1992142 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.