Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0041 | 0.0582 | 0.0209 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0041 | 0.0582 | 0.5 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0381 | 0.0381 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0041 | 0.0582 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0041 | 0.0582 | 0.0849 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.3161 | 0.3161 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0041 | 0.0689 | 0.0321 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.3161 | 0.3314 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0041 | 0.0582 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.9539 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0092 | 1 | 1 |
Echinococcus multilocularis | jun protein | 0.0092 | 1 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0041 | 0.0689 | 0.0321 |
Brugia malayi | hypothetical protein | 0.0072 | 0.6386 | 0.6386 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0041 | 0.0582 | 0.0209 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0041 | 0.0582 | 0.5 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0041 | 0.0582 | 0.0209 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0041 | 0.0582 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0092 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0582 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.6847 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0041 | 0.0582 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.3161 | 0.3161 |
Schistosoma mansoni | jun-related protein | 0.0075 | 0.6847 | 1 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0041 | 0.0582 | 0.0209 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0381 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3161 | 0.3314 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0041 | 0.0689 | 1 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0041 | 0.0582 | 0.5 |
Echinococcus granulosus | jun protein | 0.0092 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0041 | 0.0582 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0582 | 0.061 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0041 | 0.0582 | 0.0582 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0381 | 0.0556 |
Onchocerca volvulus | 0.0072 | 0.6386 | 0.5 | |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0041 | 0.0582 | 0.0849 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0041 | 0.0582 | 0.0209 |
Echinococcus granulosus | sodium channel protein | 0.0041 | 0.0689 | 0.0321 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cell cycle analysis (functional) | G2/M arrest 0 | Effect of the compound on the cell cycle progression using P388 cells at 4.0 ug/mL for 24 hr; G2/M arrest | ChEMBL. | 10866386 |
IC50 (functional) | = 0.11 ug ml-1 | In vitro antiproliferative activity measured against KB cancer cell line using MTT colorimetric assay | ChEMBL. | 10866386 |
IC50 (functional) | = 0.11 ug ml-1 | In vitro antiproliferative activity measured against KB cancer cell line using MTT colorimetric assay | ChEMBL. | 10866386 |
IC50 (functional) | = 0.14 ug ml-1 | In vitro antiproliferative activity measured against P388 cancer cell line using MTT colorimetric assay | ChEMBL. | 10866386 |
IC50 (functional) | = 0.14 ug ml-1 | In vitro antiproliferative activity measured against P388 cancer cell line using MTT colorimetric assay | ChEMBL. | 10866386 |
IC50 (functional) | = 0.18 ug ml-1 | In vitro antiproliferative activity measured against colon 38 cancer cell line using MTT colorimetric assay | ChEMBL. | 10866386 |
IC50 (functional) | = 0.18 ug ml-1 | In vitro antiproliferative activity measured against colon 38 cancer cell line using MTT colorimetric assay | ChEMBL. | 10866386 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 10866386 | |
Homo sapiens | ChEMBL23 | 10866386 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.