Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Starlite/ChEMBL | References |
Homo sapiens | activating transcription factor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.0101 | 0.3407 | 0.3407 |
Onchocerca volvulus | 0.0264 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.3407 | 1 |
Brugia malayi | Trypsin family protein | 0.0101 | 0.3407 | 0.3407 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3407 | 0.3403 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0089 | 0.2904 | 0.8525 |
Brugia malayi | Trypsin family protein | 0.0101 | 0.3407 | 0.3407 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3407 | 0.3403 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3407 | 0.3403 |
Mycobacterium ulcerans | hypothetical protein | 0.0101 | 0.3407 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.3407 | 1 |
Echinococcus granulosus | enteropeptidase | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.3407 | 1 |
Brugia malayi | Trypsin family protein | 0.0101 | 0.3407 | 0.3407 |
Loa Loa (eye worm) | trypsin family protein | 0.0101 | 0.3407 | 0.3403 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0101 | 0.3407 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3407 | 0.3403 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0101 | 0.3407 | 0.3407 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.3407 | 1 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.3407 | 1 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.3407 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0101 | 0.3407 | 1 |
Echinococcus multilocularis | enteropeptidase | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.3407 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 1 | 1 |
Echinococcus granulosus | Mastin | 0.0101 | 0.3407 | 1 |
Echinococcus multilocularis | Ankyrin | 0.0018 | 0.0006 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3407 | 0.3403 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0101 | 0.3407 | 1 |
Brugia malayi | hypothetical protein | 0.0101 | 0.3407 | 0.3407 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3407 | 0.3403 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.3407 | 1 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0101 | 0.3407 | 0.3407 |
Echinococcus granulosus | Ankyrin | 0.0018 | 0.0006 | 0.0018 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.3407 | 1 |
Echinococcus multilocularis | Mastin | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.3407 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.3407 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3407 | 0.3403 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0089 | 0.2904 | 0.8525 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.3407 | 1 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.3407 | 1 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0018 | 0.0006 | 0.0018 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.3407 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.3407 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10 uM | In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor | ChEMBL. | 9484492 |
IC50 (binding) | > 10 uM | In vitro inhibitory activity against human Jurkat T-Cells stably transfected with activating transcription factor 1 | ChEMBL. | 9484492 |
IC50 (binding) | > 10 uM | In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factor | ChEMBL. | 9484492 |
IC50 (binding) | > 10 uM | In vitro inhibitory activity against human Jurkat T-Cells stably transfected with activating transcription factor 1 | ChEMBL. | 9484492 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.