Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.1384 | 0.6036 | 1 |
Brugia malayi | Matrixin family protein | 0.0607 | 0.1865 | 0.309 |
Onchocerca volvulus | Matrilysin homolog | 0.0607 | 0.1865 | 0.3199 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.2123 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.094 | 0.3655 | 0.5 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.062 | 0.1936 | 0.3207 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.1142 | 0.4738 | 0.4738 |
Loa Loa (eye worm) | hypothetical protein | 0.1142 | 0.4738 | 0.7849 |
Chlamydia trachomatis | peptide deformylase | 0.094 | 0.3655 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0359 | 0.0535 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.1346 | 0.5829 | 1 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.062 | 0.1936 | 0.3207 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0739 | 0.2574 | 0.4265 |
Loa Loa (eye worm) | matrixin family protein | 0.1346 | 0.5829 | 0.9658 |
Schistosoma mansoni | hypothetical protein | 0.0777 | 0.2781 | 0.587 |
Brugia malayi | Matrixin family protein | 0.0607 | 0.1865 | 0.309 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.1142 | 0.4738 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.094 | 0.3655 | 0.5 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.1142 | 0.4738 | 0.4738 |
Loa Loa (eye worm) | hypothetical protein | 0.0607 | 0.1865 | 0.309 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.1142 | 0.4738 | 0.4738 |
Loa Loa (eye worm) | hypothetical protein | 0.0607 | 0.1865 | 0.309 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0359 | 0.0535 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0607 | 0.1865 | 0.3937 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.1003 | 0.3992 | 0.3992 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.1003 | 0.3992 | 0.3992 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.094 | 0.3655 | 1 |
Onchocerca volvulus | 0.0777 | 0.2781 | 0.4771 | |
Treponema pallidum | polypeptide deformylase (def) | 0.094 | 0.3655 | 0.5 |
Onchocerca volvulus | 0.0607 | 0.1865 | 0.3199 | |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0359 | 0.0535 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0607 | 0.1865 | 0.309 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.2574 | 0.4265 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0359 | 0.0535 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0777 | 0.2781 | 0.4607 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0269 | 0.0051 | 0.0107 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.1142 | 0.4738 | 0.4738 |
Plasmodium falciparum | peptide deformylase | 0.094 | 0.3655 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.1384 | 0.6036 | 1 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.1142 | 0.4738 | 0.5 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0607 | 0.1865 | 0.309 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.1003 | 0.3992 | 0.6614 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0359 | 0.0535 | 0.5 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1142 | 0.4738 | 1 |
Brugia malayi | Matrixin family protein | 0.0607 | 0.1865 | 0.309 |
Mycobacterium ulcerans | peptide deformylase | 0.094 | 0.3655 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0359 | 0.0535 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.094 | 0.3655 | 1 |
Brugia malayi | Matrixin family protein | 0.0607 | 0.1865 | 0.309 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0359 | 0.0535 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.1346 | 0.5829 | 1 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.1003 | 0.3992 | 0.6614 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | 0 nM | Binding affinity of the compound was evaluated by calculating competition for [3H]-N-0437 binding on Dopamine receptor D2L of CHO K-1 cells; ND means Not determined | ChEMBL. | 8863800 |
Ki (binding) | = 1372 nM | Binding affinity was evaluated by calculating competition for [3H]-spiperone binding on Dopamine receptor D3 expressed on CHO K-1 cells. | ChEMBL. | 8863800 |
Ki (binding) | = 1372 nM | Binding affinity was evaluated by calculating competition for [3H]-spiperone binding on Dopamine receptor D3 expressed on CHO K-1 cells. | ChEMBL. | 8863800 |
Ki (binding) | > 3333 nM | Binding affinity was evaluated by calculating competition for [3H]-spiperone binding on Dopamine receptor D4.2 of CHO K-1 cells. | ChEMBL. | 8863800 |
Ki (binding) | > 3333 nM | Binding affinity was evaluated by calculating competition for [3H]-spiperone binding on Dopamine receptor D4.2 of CHO K-1 cells. | ChEMBL. | 8863800 |
Ki (binding) | = 58882 nM | Binding affinity was evaluated by calculating competition for [3H]-spiperone binding on Dopamine receptor D2L of CHO K-1 cells. | ChEMBL. | 8863800 |
Ki (binding) | = 58882 nM | Binding affinity was evaluated by calculating competition for [3H]-spiperone binding on Dopamine receptor D2L of CHO K-1 cells. | ChEMBL. | 8863800 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.