Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | 0.967 | 1 | 0.5 |
Mycobacterium tuberculosis | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) ( | 0.7448 | 0.7473 | 0.5 |
Plasmodium falciparum | hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase | 0.2993 | 0.2407 | 0.5 |
Chlamydia trachomatis | bifunctional 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase | 0.2993 | 0.2407 | 0.5 |
Plasmodium vivax | hydroxymethylpterin pyrophosphokinase-dihydropteroate synthetase, putative | 0.2993 | 0.2407 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0876 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.7812 | 0.7888 | 0.5 |
Toxoplasma gondii | dihydropteroate synthase | 0.2993 | 0.2407 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 148 uM | Antileishmanial activity of compound against leishmania donovani was determined in luciferase assay | ChEMBL. | 13678403 |
IC50 (functional) | = 148 uM | Antileishmanial activity of compound against leishmania donovani was determined in luciferase assay | ChEMBL. | 13678403 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.