Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 19, subfamily A, polypeptide 1 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 17, subfamily A, polypeptide 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | cytochrome P450, family 17, subfamily A, polypeptide 1 | 508 aa | 468 aa | 25.2 % |
Trypanosoma cruzi | cytochrome P450, putative | cytochrome P450, family 19, subfamily A, polypeptide 1 | 503 aa | 425 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0253 | 0.1976 | 0.2488 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0421 | 0.543 | 0.6836 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0389 | 0.4774 | 0.601 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0223 | 0.1353 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0389 | 0.4774 | 0.601 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0253 | 0.1976 | 0.2488 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0223 | 0.1353 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0253 | 0.1976 | 0.2488 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0223 | 0.1353 | 0.1703 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0253 | 0.1976 | 0.2488 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0253 | 0.1976 | 0.2488 |
Echinococcus granulosus | glutamate receptor 2 | 0.0253 | 0.1976 | 0.2488 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0253 | 0.1976 | 0.2488 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0389 | 0.4774 | 0.3957 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0391 | 0.4807 | 0.6051 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0223 | 0.1353 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0421 | 0.543 | 0.6836 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0223 | 0.1353 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0544 | 0.7943 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0253 | 0.1976 | 0.2488 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0253 | 0.1976 | 0.2488 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0253 | 0.1976 | 0.2488 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0391 | 0.4807 | 0.6051 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0544 | 0.7943 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9 nM | Tested for inhibition of human testicular C17,20-Lyase. | ChEMBL. | 7473546 |
IC50 (binding) | = 9 nM | Tested for inhibition of human testicular C17,20-Lyase. | ChEMBL. | 7473546 |
IC50 (binding) | = 34 nM | Tested for inhibition of human testicular Steroid 17-alpha-hydroxylase/17,20 lyase | ChEMBL. | 7473546 |
IC50 (binding) | = 34 nM | Tested for inhibition of human testicular Steroid 17-alpha-hydroxylase/17,20 lyase | ChEMBL. | 7473546 |
IC50 (binding) | = 3.96 uM | Tested for inhibition of human placental Cytochrome P450 19A1 | ChEMBL. | 7473546 |
IC50 (binding) | = 3.96 uM | Tested for inhibition of human placental Cytochrome P450 19A1 | ChEMBL. | 7473546 |
T1/2 (ADMET) | = 88 min | Hydrolysis rate of the compound by rat liver microsomal esterase | ChEMBL. | 7473546 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.