Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.0799 | 0.0799 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.2172 | 0.9163 | 1 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0198 | 0.0799 | 0.5 |
Loa Loa (eye worm) | glycerol-3-phosphate dehydrogenase | 0.0198 | 0.0799 | 0.0799 |
Brugia malayi | SRC-1 | 0.0045 | 0.0155 | 0.1935 |
Schistosoma mansoni | tyrosine kinase | 0.0045 | 0.0155 | 0.0155 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase, putative | 0.0198 | 0.0799 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.004 | 0.013 | 0.1632 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.237 | 1 | 1 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0198 | 0.0799 | 0.5 |
Schistosoma mansoni | NAD dehydrogenase | 0.0198 | 0.0799 | 0.0799 |
Plasmodium vivax | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0198 | 0.0799 | 0.5 |
Echinococcus multilocularis | glycerol 3 phosphate dehydrogenase | 0.0198 | 0.0799 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0045 | 0.0155 | 0.0155 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0045 | 0.0155 | 0.1935 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0045 | 0.0155 | 0.1935 |
Brugia malayi | RE18450p | 0.0198 | 0.0799 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0045 | 0.0155 | 0.1935 |
Onchocerca volvulus | Dimethylglycine dehydrogenase, mitochondrial homolog | 0.0198 | 0.0799 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.001 | 0.0005 | 0.0068 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.001 | 0.0005 | 0.0068 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0036 | 0.0117 | 0.1459 |
Entamoeba histolytica | anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative | 0.0198 | 0.0799 | 1 |
Brugia malayi | cDNA sequence BC016226 | 0.0198 | 0.0799 | 1 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0198 | 0.0799 | 0.5 |
Echinococcus multilocularis | FAD dependent oxidoreductase domain containing protein | 0.0198 | 0.0799 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0045 | 0.0155 | 0.1935 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.0799 | 0.0799 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0045 | 0.0155 | 0.1935 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0045 | 0.0155 | 0.1935 |
Loa Loa (eye worm) | TK protein kinase | 0.0036 | 0.0117 | 0.0117 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.001 | 0.0005 | 0.0005 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0198 | 0.0799 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0041 | 0.0136 | 0.0136 |
Schistosoma mansoni | ATP:guanidino kinase (Smc74) | 0.0198 | 0.0799 | 0.0799 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0045 | 0.0155 | 0.1935 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0045 | 0.0155 | 0.1935 |
Toxoplasma gondii | hypothetical protein | 0.0198 | 0.0799 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0041 | 0.0136 | 0.17 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0041 | 0.0136 | 0.17 |
Leishmania major | hypothetical protein, conserved | 0.0198 | 0.0799 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 20 | 0.0198 | 0.0799 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0041 | 0.0136 | 0.17 |
Echinococcus granulosus | FAD dependent oxidoreductase domain containing protein | 0.0198 | 0.0799 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0041 | 0.0136 | 0.17 |
Trypanosoma cruzi | FAD dependent oxidoreductase, putative | 0.0198 | 0.0799 | 0.5 |
Chlamydia trachomatis | D-amino acid dehydrogenase | 0.0198 | 0.0799 | 0.5 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0198 | 0.0799 | 1 |
Echinococcus granulosus | glycerol 3 phosphate dehydrogenase | 0.0198 | 0.0799 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.004 | 0.013 | 0.1632 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.237 | 1 | 1 |
Schistosoma mansoni | fad oxidoreductase | 0.0198 | 0.0799 | 0.0799 |
Brugia malayi | protein-tyrosine kinase | 0.0041 | 0.0136 | 0.17 |
Leishmania major | hypothetical protein, conserved | 0.0198 | 0.0799 | 0.5 |
Toxoplasma gondii | FAD-dependent glycerol-3-phosphate dehydrogenase | 0.0198 | 0.0799 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0045 | 0.0155 | 0.1935 |
Onchocerca volvulus | Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog | 0.0198 | 0.0799 | 0.5 |
Schistosoma mansoni | fad oxidoreductase | 0.0198 | 0.0799 | 0.0799 |
Schistosoma mansoni | d-amino acid oxidase | 0.237 | 1 | 1 |
Leishmania major | glycerol-3-phosphate dehydrogenase-like protein | 0.0198 | 0.0799 | 0.5 |
Trypanosoma brucei | FAD dependent oxidoreductase, putative | 0.0198 | 0.0799 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0045 | 0.0155 | 0.1935 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0036 | 0.0117 | 0.1459 |
Echinococcus multilocularis | c src tyrosine kinase | 0.001 | 0.0005 | 0.0068 |
Brugia malayi | dimethylglycine dehydrogenase, mitochondrial precursor, putative | 0.0198 | 0.0799 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0045 | 0.0155 | 0.1935 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0045 | 0.0155 | 0.1935 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0041 | 0.0136 | 0.17 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0045 | 0.0155 | 0.1935 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0045 | 0.0155 | 0.1935 |
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0198 | 0.0799 | 0.5 |
Trypanosoma brucei | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0198 | 0.0799 | 0.5 |
Schistosoma mansoni | glycerol-3-phosphate dehydrogenase | 0.0198 | 0.0799 | 0.0799 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.0005 | 0.0005 |
Schistosoma mansoni | tyrosine kinase | 0.0045 | 0.0155 | 0.0155 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial | 0.0198 | 0.0799 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.001 | 0.0005 | 0.0068 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0198 | 0.0799 | 0.5 |
Brugia malayi | pyruvate dehydrogenase phosphatase regulatory subunit precursor | 0.0198 | 0.0799 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0045 | 0.0155 | 0.1935 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.001 | 0.0005 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.0799 | 0.0799 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.0005 | 0.0005 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.001 | 0.0005 | 0.0068 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0045 | 0.0155 | 0.1935 |
Plasmodium falciparum | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0198 | 0.0799 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0045 | 0.0155 | 0.1935 |
Trypanosoma brucei | electron transfer flavoprotein-ubiquinone oxidoreductase, putative | 0.0198 | 0.0799 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0041 | 0.0136 | 0.17 |
Onchocerca volvulus | Putative fad oxidoreductase | 0.0198 | 0.0799 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.4 uM | Binding affinity to p60 src SH2 domain. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.