Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0378 | 0.5828 | 0.897 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0244 | 0.0326 | 0.0502 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0272 | 0.1448 | 0.2229 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0244 | 0.0326 | 0.0502 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0395 | 0.6498 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0378 | 0.5828 | 0.897 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0272 | 0.1448 | 0.2229 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0395 | 0.6498 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | nM | Binding affinity was evaluated by calculating competition for [3H]-N-0437 binding on Dopamine receptor D2L of CHO K-1 cells; Not determined | ChEMBL. | 8863800 |
Ki (binding) | 0 nM | Binding affinity was evaluated by calculating competition for [3H]-N-0437 binding on Dopamine receptor D2L of CHO K-1 cells; Not determined | ChEMBL. | 8863800 |
Ki (binding) | = 120 nM | Binding affinity was evaluated by calculating competition for [3H]-spiperone binding on Dopamine receptor D2L of CHO K-1 cells. | ChEMBL. | 8863800 |
Ki (binding) | = 120 nM | Binding affinity was evaluated by calculating competition for [3H]-spiperone binding on Dopamine receptor D2L of CHO K-1 cells. | ChEMBL. | 8863800 |
Ki (binding) | = 857 nM | Binding affinity was evaluated by calculating competition for [3H]-spiperone binding on Dopamine receptor D3 expressed on CHO K-1 cells. | ChEMBL. | 8863800 |
Ki (binding) | = 857 nM | Binding affinity was evaluated by calculating competition for [3H]-spiperone binding on Dopamine receptor D3 expressed on CHO K-1 cells. | ChEMBL. | 8863800 |
Ki (binding) | = 964 nM | Binding affinity was evaluated by calculating competition for [3H]-spiperone binding on Dopamine receptor D4.2 of CHO K-1 cells. | ChEMBL. | 8863800 |
Ki (binding) | = 964 nM | Binding affinity was evaluated by calculating competition for [3H]-spiperone binding on Dopamine receptor D4.2 of CHO K-1 cells. | ChEMBL. | 8863800 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.