Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cyclin A, putative | 0.0067 | 0.2008 | 0.1685 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0049 | 0.1045 | 0.3552 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0049 | 0.1045 | 0.1045 |
Trichomonas vaginalis | AGC family protein kinase | 0.0213 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.1045 | 0.0683 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0515 | 0.0131 |
Toxoplasma gondii | NIMA-related protein kinase NIMA1 | 0.0213 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0067 | 0.2008 | 0.1685 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0049 | 0.1045 | 0.3552 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0049 | 0.1045 | 0.3552 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.1045 | 0.3552 |
Trichomonas vaginalis | cyclins, putative | 0.0039 | 0.0515 | 0.0131 |
Brugia malayi | cell division control protein 2 homolog | 0.0049 | 0.1045 | 0.3552 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0049 | 0.1045 | 0.3552 |
Trichomonas vaginalis | cyclins, putative | 0.0067 | 0.2008 | 0.1685 |
Trypanosoma cruzi | cyclin, putative | 0.0067 | 0.2008 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0049 | 0.1045 | 0.3552 |
Onchocerca volvulus | 0.0067 | 0.2008 | 0.5 | |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0049 | 0.1045 | 0.3552 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0049 | 0.1045 | 0.3552 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2008 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0049 | 0.1045 | 0.0559 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.1045 | 0.3552 |
Entamoeba histolytica | cyclin, putative | 0.0067 | 0.2008 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0067 | 0.2008 | 0.1685 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0067 | 0.2008 | 1 |
Plasmodium vivax | NIMA-related protein kinase (Pfnek-1), putative | 0.0213 | 1 | 1 |
Echinococcus granulosus | cyclin B | 0.0067 | 0.2008 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0039 | 0.0515 | 0.0131 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0049 | 0.1045 | 0.3552 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0049 | 0.1045 | 0.3552 |
Trichomonas vaginalis | cyclin B, putative | 0.0067 | 0.2008 | 0.1685 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2008 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0947 | 0.2896 |
Trichomonas vaginalis | cyclin B, putative | 0.0067 | 0.2008 | 0.1685 |
Trichomonas vaginalis | cyclin B3, putative | 0.0039 | 0.0515 | 0.0131 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0067 | 0.2008 | 1 |
Schistosoma mansoni | cyclin B | 0.0067 | 0.2008 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0067 | 0.2008 | 0.1685 |
Trichomonas vaginalis | cyclins, putative | 0.0067 | 0.2008 | 0.1685 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0067 | 0.2008 | 0.1574 |
Plasmodium falciparum | protein kinase 5 | 0.0049 | 0.1045 | 0.0559 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0067 | 0.2008 | 1 |
Leishmania major | cyclin | 0.0067 | 0.2008 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0039 | 0.0515 | 0.0131 |
Brugia malayi | Protein kinase domain containing protein | 0.0049 | 0.1045 | 0.3552 |
Trichomonas vaginalis | STE family protein kinase | 0.0213 | 1 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.0067 | 0.2008 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.1045 | 0.0683 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0049 | 0.1045 | 0.3552 |
Echinococcus multilocularis | cyclin B | 0.0067 | 0.2008 | 1 |
Plasmodium falciparum | NIMA related kinase 1 | 0.0213 | 1 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0067 | 0.2008 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0067 | 0.2008 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0039 | 0.0515 | 0.0131 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0049 | 0.1045 | 0.3552 |
Giardia lamblia | Kinase, NEK | 0.0213 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0067 | 0.2008 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0049 | 0.1045 | 0.3552 |
Giardia lamblia | Kinase, NEK | 0.0213 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0049 | 0.1045 | 0.0559 |
Trichomonas vaginalis | cyclin B, putative | 0.0067 | 0.2008 | 0.1685 |
Echinococcus granulosus | cyclin dependent kinase | 0.0049 | 0.1045 | 0.3552 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.1045 | 0.0683 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log k' (ADMET) | = 0.3299 | HPLC capacity factor (k') | ChEMBL. | 7990118 |
MIC (functional) | = 0.015 ug ml-1 | In vitro minimum inhibitory concentration for Bacillus subtilis ATCC 6633 | ChEMBL. | 7990118 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimum inhibitory concentration for Bacillus cereus ATCC 11778 | ChEMBL. | 7990118 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimum inhibitory concentration for Staphylococcus aureus ATCC 25178 | ChEMBL. | 7990118 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimum inhibitory concentration for Staphylococcus epidermidis ATCC 155-1 | ChEMBL. | 7990118 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimum inhibitory concentration for Proteus vulgaris ATCC 8427 | ChEMBL. | 7990118 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimum inhibitory concentration to inhibit Klebsiella pneumoniae ATCC 10031 | ChEMBL. | 7990118 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimum inhibitory concentration for Enterobacter cloacae ATCC 23355 | ChEMBL. | 7990118 |
MIC (functional) | = 0.5 ug ml-1 | In vitro minimum inhibitory concentration for Morganella morganii ATCC 8019 | ChEMBL. | 7990118 |
MIC (functional) | = 0.5 ug ml-1 | In vitro minimum inhibitory concentration for Escherichia coli ATCC 10799 | ChEMBL. | 7990118 |
MIC (functional) | = 0.5 ug ml-1 | In vitro minimum inhibitory concentration for Escherichia coli ATCC 10799 | ChEMBL. | 7990118 |
MIC (functional) | = 2 ug ml-1 | In vitro minimum inhibitory concentration for Streptococcus faecalis ATCC 10541 | ChEMBL. | 7990118 |
MIC (functional) | = 4 ug ml-1 | In vitro minimum inhibitory concentration for Pseudomonas aeruginosa ATCC 10145 | ChEMBL. | 7990118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.