Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0325 | 0.0345 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | adenoreceptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0414 | 0.0531 | 0.5 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0325 | 0.0345 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Schistosoma mansoni | opsin-like receptor | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Brugia malayi | Dopamine receptor protein 1 | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Mycobacterium tuberculosis | Probable anthranilate phosphoribosyltransferase TrpD | 0.1403 | 0.2586 | 0.2586 |
Schistosoma mansoni | neuropeptide receptor | 0.0414 | 0.0531 | 0.5 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.4969 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0414 | 0.0531 | 0.5 |
Mycobacterium ulcerans | anthranilate phosphoribosyltransferase | 0.1403 | 0.2586 | 0.2586 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | histamine h1 receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0414 | 0.0531 | 0.5 |
Echinococcus multilocularis | thymidine phosphorylase | 0.4969 | 1 | 1 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | AKH receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | myosin xvIII | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0414 | 0.0531 | 0.5 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.1403 | 0.2586 | 1 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.4969 | 1 | 1 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | RE15519p | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0414 | 0.0531 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6400 ug ml-1 | Minimum concentration required to inhibit Staphylococcus aureus ATCC25923 | ChEMBL. | 12954069 |
MIC (functional) | = 12800 ug ml-1 | Minimum concentration required to inhibit Enterococcus faecalis ATCC29212 | ChEMBL. | 12954069 |
MIC (functional) | = 12800 ug ml-1 | Minimum concentration required to inhibit Escherichia coli ATCC25922 | ChEMBL. | 12954069 |
MIC (functional) | = 12800 ug ml-1 | Minimum concentration required to inhibit Pseudomonas aeruginosa ATCC27853 | ChEMBL. | 12954069 |
MIC (functional) | = 12800 ug ml-1 | Minimum concentration required to inhibit Escherichia coli ATCC25922 | ChEMBL. | 12954069 |
MLC (functional) | = 12800 ug ml-1 | Minimum concentration required to inhibit Enterococcus faecalis ATCC29212 | ChEMBL. | 12954069 |
MLC (functional) | = 12800 ug ml-1 | Minimum concentration required to inhibit Staphylococcus aureus ATCC25923 | ChEMBL. | 12954069 |
MLC (functional) | = 12800 ug ml-1 | Minimum concentration required to inhibit Escherichia coli ATCC25922 | ChEMBL. | 12954069 |
MLC (functional) | = 12800 ug ml-1 | Minimum concentration required to inhibit Pseudomonas aeruginosa ATCC27853 | ChEMBL. | 12954069 |
MLC (functional) | = 12800 ug ml-1 | Minimum concentration required to inhibit Escherichia coli ATCC25922 | ChEMBL. | 12954069 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.