Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.029 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 35 uM | Inhibitory activity against bacteria in the transcription/translation assay | ChEMBL. | 14980669 |
MIC (functional) | = 1.5 uM | Minimal inhibitory concentration against gram positive Enterococcus hirae 29212 strain (Range is 0.75-1.5 microM) | ChEMBL. | 14980669 |
MIC (functional) | = 7 uM | Minimal inhibitory concentration against gram positive Staphylococcus aureus 13709 strain (Range is 3-7 microM) | ChEMBL. | 14980669 |
MIC (functional) | = 12 uM | Minimal inhibitory concentration against gram positive Streptococcus pneumoniae 6303 strain (Range is 6-12 microM) | ChEMBL. | 14980669 |
MIC (functional) | = 12 uM | Minimal inhibitory concentration against gram negative Pseudomonas aeruginosa 25416 strain (Range is 6-12 microM) | ChEMBL. | 14980669 |
MIC (functional) | = 25 uM | Minimal inhibitory concentration against Staphylococcus aureus (Range is 12-25 microM) | ChEMBL. | 14980669 |
MIC (functional) | = 25 uM | Minimal inhibitory concentration against Escherichia coli (Range is 12-25 microM) | ChEMBL. | 14980669 |
MIC (functional) | = 25 uM | Minimal inhibitory concentration against Escherichia coli (Range is 12-25 microM) | ChEMBL. | 14980669 |
MIC (functional) | = 26 uM | Minimal inhibitory concentration against gram negative Escherichia coli 25922 strain (Range is 12-26 microM) | ChEMBL. | 14980669 |
MIC (functional) | = 26 uM | Minimal inhibitory concentration against gram negative Escherichia coli 25922 strain (Range is 12-26 microM) | ChEMBL. | 14980669 |
MIC (functional) | = 50 uM | Minimal inhibitory concentration against gram positive Streptococcus pyogenes 49399 strain (Range is 25-50 microM) | ChEMBL. | 14980669 |
MIC (functional) | = 50 uM | Minimal inhibitory concentration against gram negative Proteus vulgaris 8427 strain (Range is 25-50 microM) | ChEMBL. | 14980669 |
MIC (functional) | = 50 uM | Minimal inhibitory concentration against gram negative Klebsiella pneumoniae 13383 strain (Range is 25-50 microM) | ChEMBL. | 14980669 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.