Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 5.8 | Calculated partition coefficient (clogP) | ChEMBL. | 7996539 |
pKb (binding) | < 5 | In vitro antimuscarinic activity against the M2 muscarinic receptor subtype in guinea pig atria | ChEMBL. | 7996539 |
pKb (binding) | = 6 | In vitro antimuscarinic activity against the M3 muscarinic receptor subtype in rat bladder | ChEMBL. | 7996539 |
pKb (binding) | = 6.7 | In vitro antimuscarinic activity against the M3 muscarinic receptor subtype in rat ileum | ChEMBL. | 7996539 |
pKb (binding) | < 5 | In vitro antimuscarinic activity against the M2 muscarinic receptor subtype in guinea pig atria | ChEMBL. | 7996539 |
pKb (binding) | = 6 | In vitro antimuscarinic activity against the M3 muscarinic receptor subtype in rat bladder | ChEMBL. | 7996539 |
pKb (binding) | = 6.7 | In vitro antimuscarinic activity against the M3 muscarinic receptor subtype in rat ileum | ChEMBL. | 7996539 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.