Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, NEK | 0.0213 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0067 | 0.2008 | 0.1685 |
Plasmodium vivax | NIMA-related protein kinase (Pfnek-1), putative | 0.0213 | 1 | 1 |
Giardia lamblia | Kinase, NEK | 0.0213 | 1 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0067 | 0.2008 | 0.1574 |
Trichomonas vaginalis | cyclin B, putative | 0.0067 | 0.2008 | 0.1685 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0947 | 0.2896 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0049 | 0.1045 | 0.3552 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0067 | 0.2008 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.1045 | 0.3552 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0049 | 0.1045 | 0.3552 |
Trichomonas vaginalis | cyclins, putative | 0.0067 | 0.2008 | 0.1685 |
Trichomonas vaginalis | cyclin D, putative | 0.0039 | 0.0515 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2008 | 1 |
Plasmodium falciparum | NIMA related kinase 1 | 0.0213 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0067 | 0.2008 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0213 | 1 | 1 |
Toxoplasma gondii | NIMA-related protein kinase NIMA1 | 0.0213 | 1 | 1 |
Trichomonas vaginalis | cyclin B3, putative | 0.0039 | 0.0515 | 0.0131 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0049 | 0.1045 | 0.1045 |
Trypanosoma cruzi | cyclin, putative | 0.0067 | 0.2008 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0213 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0049 | 0.1045 | 0.3552 |
Trypanosoma cruzi | cyclin, putative | 0.0067 | 0.2008 | 1 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0049 | 0.1045 | 0.3552 |
Brugia malayi | Protein kinase domain containing protein | 0.0049 | 0.1045 | 0.3552 |
Trichomonas vaginalis | cyclin B, putative | 0.0067 | 0.2008 | 0.1685 |
Trichomonas vaginalis | cyclin D, putative | 0.0039 | 0.0515 | 0.0131 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0049 | 0.1045 | 0.3552 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0049 | 0.1045 | 0.3552 |
Trichomonas vaginalis | cyclins, putative | 0.0067 | 0.2008 | 0.1685 |
Giardia lamblia | Kinase, CMGC CDK | 0.0049 | 0.1045 | 0.0559 |
Giardia lamblia | Kinase, CMGC CDK | 0.0049 | 0.1045 | 0.0559 |
Trichomonas vaginalis | cyclins, putative | 0.0039 | 0.0515 | 0.0131 |
Trichomonas vaginalis | cyclins, putative | 0.0067 | 0.2008 | 0.1685 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0049 | 0.1045 | 0.3552 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.1045 | 0.0683 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0049 | 0.1045 | 0.3552 |
Trypanosoma cruzi | cyclin 6, putative | 0.0067 | 0.2008 | 1 |
Leishmania major | cyclin | 0.0067 | 0.2008 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0049 | 0.1045 | 0.3552 |
Trichomonas vaginalis | cyclin B, putative | 0.0067 | 0.2008 | 0.1685 |
Echinococcus multilocularis | cyclin B | 0.0067 | 0.2008 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0067 | 0.2008 | 1 |
Onchocerca volvulus | 0.0067 | 0.2008 | 0.5 | |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0067 | 0.2008 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0067 | 0.2008 | 0.1685 |
Brugia malayi | cell division control protein 2 homolog | 0.0049 | 0.1045 | 0.3552 |
Schistosoma mansoni | cyclin B | 0.0067 | 0.2008 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.1045 | 0.0683 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.1045 | 0.0683 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0049 | 0.1045 | 0.3552 |
Trichomonas vaginalis | cyclin B, putative | 0.0039 | 0.0515 | 0.0131 |
Echinococcus granulosus | cyclin dependent kinase | 0.0049 | 0.1045 | 0.3552 |
Plasmodium falciparum | protein kinase 5 | 0.0049 | 0.1045 | 0.0559 |
Trichomonas vaginalis | cyclins, putative | 0.0067 | 0.2008 | 0.1685 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0049 | 0.1045 | 0.3552 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.1045 | 0.3552 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0049 | 0.1045 | 0.3552 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0067 | 0.2008 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0067 | 0.2008 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0515 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2008 | 1 |
Echinococcus granulosus | cyclin B | 0.0067 | 0.2008 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log k' (ADMET) | = 0.4068 | HPLC capacity factor (k') | ChEMBL. | 7990118 |
MIC (functional) | = 0.015 ug ml-1 | In vitro minimum inhibitory concentration for Bacillus subtilis ATCC 6633 | ChEMBL. | 7990118 |
MIC (functional) | = 0.015 ug ml-1 | In vitro minimum inhibitory concentration to inhibit Klebsiella pneumoniae ATCC 10031 | ChEMBL. | 7990118 |
MIC (functional) | = 0.06 ug ml-1 | In vitro minimum inhibitory concentration for Bacillus cereus ATCC 11778 | ChEMBL. | 7990118 |
MIC (functional) | = 0.06 ug ml-1 | In vitro minimum inhibitory concentration for Staphylococcus epidermidis ATCC 155-1 | ChEMBL. | 7990118 |
MIC (functional) | = 0.06 ug ml-1 | In vitro minimum inhibitory concentration for Proteus vulgaris ATCC 8427 | ChEMBL. | 7990118 |
MIC (functional) | = 0.12 ug ml-1 | In vitro minimum inhibitory concentration for Staphylococcus aureus ATCC 25178 | ChEMBL. | 7990118 |
MIC (functional) | = 0.12 ug ml-1 | In vitro minimum inhibitory concentration for Enterobacter cloacae ATCC 23355 | ChEMBL. | 7990118 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimum inhibitory concentration for Morganella morganii ATCC 8019 | ChEMBL. | 7990118 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimum inhibitory concentration for Escherichia coli ATCC 10799 | ChEMBL. | 7990118 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimum inhibitory concentration for Escherichia coli ATCC 10799 | ChEMBL. | 7990118 |
MIC (functional) | = 2 ug ml-1 | In vitro minimum inhibitory concentration for Streptococcus faecalis ATCC 10541 | ChEMBL. | 7990118 |
MIC (functional) | = 2 ug ml-1 | In vitro minimum inhibitory concentration for Pseudomonas aeruginosa ATCC 10145 | ChEMBL. | 7990118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.