Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | peroxidasin | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.4668 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.4668 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.4668 | 0.5 | 0.5 |
Onchocerca volvulus | 0.4668 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.4668 | 0.5 | 0.5 |
Onchocerca volvulus | 0.4668 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.4668 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4668 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4668 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.4668 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4668 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.4668 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.4668 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.4668 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4668 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.4668 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4668 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.4668 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4668 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.4668 | 0.5 | 0.5 |
Onchocerca volvulus | 0.4668 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.4668 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease (functional) | = 8.5 % | Plasma cholesterol lowering effect was determined in Sprague-Dawley rats at a dose of 1 mg/kg/day for 4 days | ChEMBL. | 14643317 |
RBA (binding) | = 460 | Binding affinity towards estrogen receptor (ER) using [3H]-17-beta-estradiol as radioligand in human breast cancer MCF-7 cells relative to compound 1 | ChEMBL. | 14643317 |
RBA (binding) | = 460 | Binding affinity towards estrogen receptor (ER) using [3H]-17-beta-estradiol as radioligand in human breast cancer MCF-7 cells relative to compound 1 | ChEMBL. | 14643317 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.