Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Cytochrome P450 19A1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | Cytochrome P450 19A1 | 508 aa | 450 aa | 21.1 % |
Dictyostelium discoideum | cytochrome P450 family protein | Cytochrome P450 19A1 | 508 aa | 465 aa | 21.5 % |
Drosophila melanogaster | Cytochrome P450-4d1 | Cytochrome P450 19A1 | 508 aa | 464 aa | 24.6 % |
Dictyostelium discoideum | cytochrome P450 family protein | Cytochrome P450 19A1 | 508 aa | 473 aa | 18.8 % |
Brugia malayi | Cytochrome P450 family protein | Cytochrome P450 19A1 | 508 aa | 448 aa | 20.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0112 | 0.3064 | 0.5274 | |
Echinococcus multilocularis | thymidylate synthase | 0.0112 | 0.3064 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0157 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0157 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0112 | 0.3064 | 0.0775 |
Echinococcus granulosus | thymidylate synthase | 0.0112 | 0.3064 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.013 | 0.581 | 1 |
Brugia malayi | thymidylate synthase | 0.0112 | 0.3064 | 0.0775 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0157 | 1 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.011 | 0.2833 | 0.4876 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.013 | 0.581 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.581 | 1 |
Brugia malayi | Trypsin family protein | 0.013 | 0.581 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0112 | 0.3064 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0112 | 0.3064 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0112 | 0.3064 | 0.0775 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0157 | 1 | 0.5 |
Onchocerca volvulus | 0.013 | 0.581 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.581 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0112 | 0.3064 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0157 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.03 uM | In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome | ChEMBL. | 2296032 |
EC50 (binding) | = 0.03 uM | In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome | ChEMBL. | 2296032 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.