Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thromboxane A2 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.011 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.011 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.011 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.011 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.011 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.011 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.011 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.011 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.011 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.011 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.011 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.011 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.011 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.011 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.011 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.011 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.011 | 0.5 | 0.5 |
Onchocerca volvulus | 0.011 | 0.5 | 0.5 | |
Brugia malayi | steroid hormone receptor | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.011 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.011 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.011 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.011 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.011 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.011 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.011 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.011 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.011 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.011 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.011 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.011 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.011 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.011 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.011 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.011 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.011 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.011 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.011 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.011 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.011 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.011 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.011 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.011 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.011 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.011 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.011 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.011 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.011 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.011 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.011 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.011 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.011 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CF (binding) | = 13 | Thromboxane A2 receptor binding affinity of the compound was evaluated, which is expressed as competition factor (CF = (IC50-test) / (IC50-standard) | ChEMBL. | No reference |
CF (binding) | = 13 | Thromboxane A2 receptor binding affinity of the compound was evaluated, which is expressed as competition factor (CF = (IC50-test) / (IC50-standard) | ChEMBL. | No reference |
IC50 (functional) | = 2 uM | Compound was evaluated for the inhibition of platelet aggregation, assessed turbidometrically in citrated human platelet rich plasma (PRP) | ChEMBL. | No reference |
IC50 (functional) | = 2 uM | Compound was evaluated for the inhibition of platelet aggregation, assessed turbidometrically in citrated human platelet rich plasma (PRP) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.