Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA topoisomerase ii | 0.0273368 | 0.440612 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0194687 | 0.264632 | 0.5 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0194687 | 0.264632 | 0.055916 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0194687 | 0.264632 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0194687 | 0.264632 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0175214 | 0.221078 | 0.5 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0175214 | 0.221078 | 0.5 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0523471 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0194687 | 0.264632 | 0.0377681 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0273368 | 0.440612 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0297498 | 0.494583 | 0.258263 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0297498 | 0.494583 | 0.312701 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0194687 | 0.264632 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0194687 | 0.264632 | 0.5 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0194687 | 0.264632 | 0.5 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0220974 | 0.323428 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0523471 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0523471 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0523471 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107305 | 0.0691912 | 0.261462 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0523471 | 1 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0194687 | 0.264632 | 0.5 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0297498 | 0.494583 | 0.351132 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0194687 | 0.264632 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0107305 | 0.0691912 | 0.261462 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0175214 | 0.221078 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0523471 | 1 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0182956 | 0.238394 | 0.5 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0523471 | 1 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0523471 | 1 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0194687 | 0.264632 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0273368 | 0.440612 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0273368 | 0.440612 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.5 uM | In vitro antimalarial activity against plasmodium falciparum | ChEMBL. | 12361400 |
EC50 (functional) | = 2.5 uM | In vitro antimalarial activity against plasmodium falciparum | ChEMBL. | 12361400 |
EC50 (ADMET) | > 80 uM | Effective concentration against mouse mammary FM3A cells | ChEMBL. | 12361400 |
EC50 (ADMET) | > 80 uM | Effective concentration against mouse mammary FM3A cells | ChEMBL. | 12361400 |
Inhibition (ADMET) | = 6 % | Percent inhibition of growth against mouse mammary FM3A cells | ChEMBL. | 12361400 |
Inhibition (ADMET) | = 6 % | Percent inhibition of growth against mouse mammary FM3A cells | ChEMBL. | 12361400 |
Selectivity (functional) | > 32 | Selectivity of the compound as the ratio of EC50 value for FM3A cells to that of P. falciparum. | ChEMBL. | 12361400 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 12361400 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.