Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.017 | 0.4524 | 0.3316 |
Echinococcus granulosus | geminin | 0.0175 | 0.4861 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.4861 | 0.0616 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0263 | 1 | 1 |
Onchocerca volvulus | 0.017 | 0.4524 | 0.4524 | |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.4524 | 0.3316 |
Loa Loa (eye worm) | trypsin family protein | 0.017 | 0.4524 | 0.3316 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.4861 | 0.0616 |
Onchocerca volvulus | 0.017 | 0.4524 | 0.4524 | |
Mycobacterium ulcerans | hypothetical protein | 0.017 | 0.4524 | 0.5 |
Brugia malayi | Trypsin family protein | 0.017 | 0.4524 | 0.3316 |
Onchocerca volvulus | 0.017 | 0.4524 | 0.4524 | |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.4524 | 0.3316 |
Brugia malayi | hypothetical protein | 0.017 | 0.4524 | 0.3316 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.017 | 0.4524 | 0.3316 |
Onchocerca volvulus | 0.0263 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.4524 | 0.3316 |
Echinococcus multilocularis | geminin | 0.0175 | 0.4861 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.4524 | 0.3316 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.4524 | 0.3316 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0263 | 1 | 1 |
Brugia malayi | Trypsin-like protease protein 5 | 0.017 | 0.4524 | 0.3316 |
Onchocerca volvulus | 0.017 | 0.4524 | 0.4524 | |
Brugia malayi | Trypsin family protein | 0.017 | 0.4524 | 0.3316 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 1 | 1 |
Onchocerca volvulus | 0.017 | 0.4524 | 0.4524 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cardiotoxicity (functional) | = 456 | Cardiotoxicity measured by the ATP/protein ratio compared with untreated controls using neonatal rat heart myocyte assay. | ChEMBL. | 8960558 |
IC50 (functional) | = 4.8 nM | Activity against A549 cancer cell line. | ChEMBL. | 8960558 |
IC50 (functional) | = 4.8 nM | Activity against A549 cancer cell line. | ChEMBL. | 8960558 |
IC50 (functional) | = 6.7 nM | Antitumor activity against human ovarian OVCAR3 cell lines. | ChEMBL. | 8960558 |
IC50 (functional) | = 6.7 nM | Antitumor activity against human ovarian OVCAR3 cell lines. | ChEMBL. | 8960558 |
IC50 (functional) | = 8.1 nM | Antitumor activity against sensitive L1210 murine leukemia cell lines. | ChEMBL. | 8960558 |
IC50 (functional) | = 8.1 nM | Antitumor activity against sensitive L1210 murine leukemia cell lines. | ChEMBL. | 8960558 |
IC50 (functional) | = 12 nM | Antitumor activity against human mammary carcinoma mitoxantrane-resistant MXF7 breast cell line. | ChEMBL. | 8960558 |
IC50 (functional) | = 12 nM | Antitumor activity against human mammary carcinoma mitoxantrane-resistant MXF7 breast cell line. | ChEMBL. | 8960558 |
IC50 (functional) | = 13 nM | Activity against human colon carcinoma multi drug resistant (MDR)-WiDr cell line. | ChEMBL. | 8960558 |
IC50 (functional) | = 13 nM | Activity against human colon carcinoma multi drug resistant (MDR)-WiDr cell line. | ChEMBL. | 8960558 |
IC50 (functional) | = 15 nM | Antitumor activity against human mammary carcinoma sensitive MXF7 breast cell line. | ChEMBL. | 8960558 |
IC50 (functional) | = 15 nM | Antitumor activity against human mammary carcinoma sensitive MXF7 breast cell line. | ChEMBL. | 8960558 |
IC50 (functional) | = 16 nM | Antitumor activity against human melanoma UACC375 cell line. | ChEMBL. | 8960558 |
IC50 (functional) | = 17 nM | Activity against human colon carcinoma sensitive WiDr cell line. | ChEMBL. | 8960558 |
IC50 (functional) | = 17 nM | Activity against human colon carcinoma sensitive WiDr cell line. | ChEMBL. | 8960558 |
IC50 (functional) | = 25 nM | Antitumor activity against human mammary carcinoma doxorubicin-resistant MXF7 breast cell line. | ChEMBL. | 8960558 |
IC50 (functional) | = 25 nM | Antitumor activity against human mammary carcinoma doxorubicin-resistant MXF7 breast cell line. | ChEMBL. | 8960558 |
Toxicity ratio (functional) | = 45.6 | The quotient of the IC50 in the myocytes divided by the mean IC50 in the three cell lines | ChEMBL. | 8960558 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 8960558 | |
Mus musculus | ChEMBL23 | 8960558 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.