Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma japonicum | ko:K04165 Oamb gene product from transcript, putative | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | AT19640p | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 390 aa | 335 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0835 | 0.3578 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0488 | 0 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1457 | 1 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0488 | 0 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0568 | 0.0827 | 0.1666 |
Plasmodium vivax | transporter, putative | 0.0835 | 0.3578 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0969 | 0.4963 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0835 | 0.3578 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0969 | 0.4963 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0889 | 0.4136 | 1 |
Plasmodium vivax | serine-repeat antigen 4 (SERA) | 0.0835 | 0.3578 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0889 | 0.4136 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0889 | 0.4136 | 0.8334 |
Schistosoma mansoni | hypothetical protein | 0.0568 | 0.0827 | 0.5 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0488 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 8.9 nM | Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor | ChEMBL. | 10585208 |
EC50 (binding) | = 8.9 nM | Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor | ChEMBL. | 10585208 |
Efficacy (functional) | = 87 % | Maximum stimulation of [35S]-GTP-gammaS, binding in CHO cells expressing human 5-HT-1d relative to 5-HT | ChEMBL. | 10585208 |
Efficacy (functional) | = 87 % | Maximum stimulation of [35S]-GTP-gammaS, binding in CHO cells expressing human 5-HT-1d relative to 5-HT | ChEMBL. | 10585208 |
IC50 (binding) | = 8.1 nM | Displacement of [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells | ChEMBL. | 10585208 |
IC50 (binding) | = 8.1 nM | Displacement of [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells | ChEMBL. | 10585208 |
IC50 (binding) | = 200 nM | Displacement of [3H]-5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells | ChEMBL. | 10585208 |
IC50 (binding) | = 200 nM | Displacement of [3H]-5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells | ChEMBL. | 10585208 |
Selectivity (binding) | = 25 | Ratio of IC50 for human 5-HT1B to human 5-HT1D receptors | ChEMBL. | 10585208 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.