Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Mastin | 0.0391 | 0.5161 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.058 | 1 | 1 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0391 | 0.5161 | 0.5 |
Onchocerca volvulus | 0.0391 | 0.5161 | 0.5161 | |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0391 | 0.5161 | 0.5 |
Onchocerca volvulus | 0.0391 | 0.5161 | 0.5161 | |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0391 | 0.5161 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.058 | 1 | 1 |
Onchocerca volvulus | 0.0391 | 0.5161 | 0.5161 | |
Loa Loa (eye worm) | hypothetical protein | 0.058 | 1 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0391 | 0.5161 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0391 | 0.5161 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0391 | 0.5161 | 0.5 |
Echinococcus granulosus | enteropeptidase | 0.0391 | 0.5161 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.058 | 1 | 1 |
Onchocerca volvulus | 0.058 | 1 | 1 | |
Echinococcus multilocularis | enteropeptidase | 0.0391 | 0.5161 | 0.5 |
Echinococcus multilocularis | Mastin | 0.0391 | 0.5161 | 0.5 |
Onchocerca volvulus | 0.0391 | 0.5161 | 0.5161 | |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0391 | 0.5161 | 0.5 |
Onchocerca volvulus | 0.0391 | 0.5161 | 0.5161 | |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0391 | 0.5161 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0391 | 0.5161 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 25 mg kg-1 | Effective dose of the compound required to inhibit Staphylococcus aureus UC9213 in mice subjected to a lethal systemic infection (when administered orally) | ChEMBL. | 9871741 |
EC50 (functional) | > 25 mg kg-1 | Effective dose of the compound required to inhibit Staphylococcus aureus UC9213 in mice subjected to a lethal systemic infection (when administered orally) | ChEMBL. | 9871741 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against Staphylococcus epidermidis UC30031UC | ChEMBL. | 9871741 |
MIC (functional) | = 4 ug ml-1 | Antibacterial activity against Enterococcus faecalis UC9217 | ChEMBL. | 9871741 |
MIC (functional) | = 32 ug ml-1 | Antibacterial activity against Bacteroides fragilis UC12199 | ChEMBL. | 9871741 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.