Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | GABA-A receptor; anion channel | 555 aa | 466 aa | 31.3 % | |
Onchocerca volvulus | GABA-A receptor; anion channel | 555 aa | 516 aa | 25.4 % | |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | GABA-A receptor; anion channel | 555 aa | 583 aa | 25.4 % |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | GABA-A receptor; anion channel | 555 aa | 578 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.105 | 0.4963 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0529 | 0 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1579 | 1 | 1 |
Brugia malayi | Hemopexin family protein | 0.0616 | 0.0827 | 0.1666 |
Plasmodium vivax | transporter, putative | 0.0816 | 0.2731 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0529 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0816 | 0.2731 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0616 | 0.0827 | 0.5 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0529 | 0 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0963 | 0.4136 | 0.8334 |
Plasmodium vivax | serine-repeat antigen 4 (SERA) | 0.0816 | 0.2731 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0963 | 0.4136 | 1 |
Brugia malayi | Matrixin family protein | 0.105 | 0.4963 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0963 | 0.4136 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0816 | 0.2731 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 34 nM | Concentration that inhibits specific [3H]-flunitrazepam binding to benzodiazepine receptor in bovine brain | ChEMBL. | 6300400 |
IC50 (binding) | = 34 nM | Concentration that inhibits specific [3H]-flunitrazepam binding to benzodiazepine receptor in bovine brain | ChEMBL. | 6300400 |
Inhibition (binding) | = 49.4 % | In vivo inhibition of specific [3H]-flunitrazepam binding in mouse brain 10 minute after iv administration of 15 microM/Kg | ChEMBL. | 6300400 |
Inhibition (binding) | = 49.4 % | In vivo inhibition of specific [3H]-flunitrazepam binding in mouse brain 10 minute after iv administration of 15 microM/Kg | ChEMBL. | 6300400 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.