Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0093 | 1 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0076 | 0.5693 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0076 | 0.5693 | 0.5 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0076 | 0.5693 | 0.5693 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0093 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0093 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0093 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0093 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0093 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0076 | 0.5693 | 0.5693 |
Echinococcus granulosus | glutamate receptor 2 | 0.006 | 0.1599 | 0.1599 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0093 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0076 | 0.5693 | 0.5693 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0093 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0093 | 1 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0076 | 0.5693 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.006 | 0.1599 | 0.1599 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0093 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0076 | 0.5693 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Max fall in blood pressure (functional) | NA 0 mmHg | Antihypertensive effect after 1 mg/kg (po) administration in conscious spontaneously hypertensive rat (over a time period of 0-210 min). | ChEMBL. | 2299619 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.