Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | aldose reductase, putative | 0.0441 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0441 | 1 | 0.5 |
Onchocerca volvulus | 0.0441 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0441 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0441 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0441 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0441 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0441 | 1 | 0.5 |
Leishmania major | prostaglandin f synthase, putative | 0.0441 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0441 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0441 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0441 | 1 | 1 |
Onchocerca volvulus | 0.0441 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0441 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0441 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0441 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0441 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0441 | 1 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0441 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0441 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0441 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0441 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0441 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0441 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0441 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0441 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0441 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0441 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0441 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0441 | 1 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0441 | 1 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0441 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0441 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0441 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0441 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0441 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0441 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0441 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0441 | 1 | 0.5 |
Onchocerca volvulus | 0.0441 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0441 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0441 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0441 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0441 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0441 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0441 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0441 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0441 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0441 | 1 | 1 |
Onchocerca volvulus | 0.0441 | 1 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0441 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0441 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0441 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0441 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0441 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0441 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0441 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0441 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0441 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0441 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0441 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0441 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0441 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0441 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0441 | 1 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0441 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0441 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0441 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0441 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0441 | 1 | 0.5 |
Onchocerca volvulus | 0.0441 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0441 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0441 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0441 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0441 | 1 | 1 |
Onchocerca volvulus | 0.0441 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0441 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0441 | 1 | 0.5 |
Schistosoma mansoni | pol-related | 0.0441 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0441 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 32 % | Inhibition of guinea pig ventricular Phosphodiesterase 3 (PDE 3) at 200 uM | ChEMBL. | 9871607 |
Inhibition (binding) | = 32 % | Inhibition of guinea pig ventricular Phosphodiesterase 3 (PDE 3) at 200 uM | ChEMBL. | 9871607 |
Inhibition (binding) | = 44 % | Inhibition of guinea pig ventricular Phosphodiesterase 4 (PDE 4) at 200 uM | ChEMBL. | 9871607 |
Inhibition (binding) | = 44 % | Inhibition of guinea pig ventricular Phosphodiesterase 4 (PDE 4) at 200 uM | ChEMBL. | 9871607 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.