Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.019 | 1 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.019 | 1 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.019 | 1 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 1 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.019 | 1 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.019 | 1 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.019 | 1 | 0.5 |
Echinococcus granulosus | laminin | 0.019 | 1 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.019 | 1 | 0.5 |
Echinococcus multilocularis | laminin | 0.019 | 1 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.019 | 1 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.019 | 1 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.019 | 1 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.019 | 1 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Inhibitory activity against L 1210 cell proliferation | ChEMBL. | 12408717 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.